Study on association between polymorphism of HLA‐DRB1 alleles and Behçet's disease

Abstract

The results suggested that HLA-DRB1 alleles might play an important role in the onset and clinical manifestations of BD.

HLA–B51/B5 and the risk of Behçet's disease: A systematic review and meta‐analysis of case–control genetic association studies

“…These studies were published between 1975 and 2007, and included 1 electronic publication (print version became available in 2008) (26) and 19 publications written in non-English languages (20,30,34,36,38,40–42,46,49,60,65,70,77,81,82,88,89,95). The relevant data in 2 articles were based on 2 distinct geographic sites and ethnic populations (19,53), each of which was included as a separate population in the meta-analysis.…”

“…For rare studies reporting results for both HLA–B5 and HLA–B51 genotypes (4,25,42,80,93), only the latter data were used for all analyses. The classification criteria used were: the International Study Group for Behçet’s Disease (97), n = 36; (19–22,26, 28,32,34,43,44,48,50 –55,57,63,64,67,68,72,74 –76,78,81, 87– 89,91,92,95); 1974/1987 revised JBDRC (96,98), n = 16 (4,24,29,31,33,45,47,60–62,70,71,79,84,85,94); O’Duffy (99), n = 6 (25,27,40,66,69,93); Mason and Barnes (100), n = 4 (23,39,42,56); Cheng and Zhang (101), n = 1 (82); and multiple sets, n = 5 (30,38,46,58,73). For 12 study populations, no statements were made with respect to the criteria used to define BD cases (35–37,49,59,65,77,80,83,86,90).…”

“…These included information on mean/median age at disease onset/diagnosis (range 28–34 years) in 5 studies (28,30,32,51,54); mean/median age at study time (range 27–49.5 years) in 20 studies (22,27,39,44,46,47,51,54,55,57,58,68,69,72,81,86,88,91,93,94); percentages of males (range 28.6–90.5%) in 44 studies (22,26–28,30–33,36,39,41,43–47,51,52,54–58,60–62,65,66,68–71,75,81–83,85,86,88,91–95); and percentages of cases with ocular involvement (range 20–100%) in 32 studies (22,24,27,29–31,33,35,39,41,45–48,51,52,55–57,65,66,68,70–73,75,82,83,88,93,94), with central nervous system involvement (range 2.8–50%) in 16 studies (22,24, 30,31,39,46–48,51,55–57,72,73,75,…”

Behçet’s disease and genes within the major histocompatibility complex region

“…Although a few studies have claimed to have found a significant association between HLA class II alleles and BD [44,[63][64][65], only a small number of patients were enrolled in these studies, and no allele was consistently identified.…”

“…A number of studies have investigated the association between HLA class II genes and BD in various ethnic groups [43,44,[63][64][65][66][67][68][69], but these have reported different results. Although a few studies have claimed to have found a significant association between HLA class II alleles and BD [44,[63][64][65], only a small number of patients were enrolled in these studies, and no allele was consistently identified.…”