Study on blood markers that fluctuate before and after total joint replacement surgery

Abstract

; mso-pagination:widow-orphan; fontsize:10.0pt; font-family:"Calibri","sans-serif";} Fasting blood samples were taken from 34 OA patients classified according to the American College of Rheumatology criteria and 14 normal individuals. Body mass index (BMI) was determined for each participant. Serum analyses included cholesterol, HDL-cholesterol, triglycerides, fasting glucose, and insulinemia. Insulin resistance was evaluated by the Homeostasis model assessment of insulin resistance (HOMA-IR), with the product of fasting triglycerides x glucose (TyG index), and the TyG with adiposity status (TyG-BMI). Total osteocalcin (OC), carboxylated OC (carbOC) and undercarboxylated OC (unOC) were determined using selective ELISA. Statistical analysis of continuous variables was performed using the Mann-Whitney test whereas multivariate analysis was performed using an ANCOVA adjusted for age and BMI.