In order to further improve the stability accuracy and anti-disturbance ability of the photoelectric stabilization platform, this paper proposes disturbance separation active disturbance rejection (DSADRC) method. Disturbance separation active disturbance rejection control makes full use of the available system model information and uses disturbance separation to separate the known disturbances from the total disturbance to be estimated, and improve the estimation accuracy of expanded state observer (ESO) by reducing the load. At the same time, it gets rid of the constraints of the standard integral series type in the traditional active disturbance rejection control, and takes the actual theoretical model of the system as the compensated model of the system, thus realizing the reuse of the system controller and reducing the workload of control algorithm design. And through simulation experiments, the DSADRC method is compared with the commonly used expected frequency characteristic method (EF), linear active disturbance rejection control (LADRC), model-assisted linear active disturbance rejection (MLADRC), and the experimental results show that: The DSADRC has better dynamic response performance and disturbance suppression ability.