Study on Chemical Profile and Neuroprotective Activity of Myrica rubra Leaf Extract

Chen, Pinghong; Lin, Xianzong; Yang, Ching-Hsu; Tang, Xu; Chang, Yuh Lih; Zheng, Weibing; Luo, Lianzhong; Xu, Chaochao; Chen, Yung-Husan

doi:10.3390/molecules22071226

Cited by 11 publications

(10 citation statements)

References 47 publications

(53 reference statements)

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“…Neuroprotective effects [32] 80% increase in N2a cells viability treated with 0.84 mM and 100 mM H2O2…”

Section: In Vitro Activitiesmentioning

confidence: 99%

“…Decrease of 28% in lipid accumulation when compared to the untreated cells. Neuroprotective effects [32] 80% increase in N2a cells viability treated with 0. 84 Methanol extract of Myrica rubra (Lour.)…”

Section: In Vitro Activitiesmentioning

confidence: 99%

“…Killick leaves [55] Methanol extract of Myrica gale L. seeds [54] Cryptostrobin (31) Dichloromethane extract of Morella serrata (Lam.) Killick leaves [55] Demethoximatteucinol-7methoxy (32) Methanol extract of Myrica gale L. seeds [54] Fruit exudate from the Myrica gale L. fruits [53,56] Demethoxymatteucinol (30) Molecules 2020, 25, x FOR PEER REVIEW 20 of 33 Killick leaves [55] Myrigalone P (27) Methanol extract of Myrica gale L. seeds [54] Uvangoletin (28) Methanol extract of Myrica gale L. seeds [54] Angoletin (29) Fruit exudate from the Myrica gale L. fruits [53,56] Demethoxymatteucinol (30) Dichloromethane extract of Morella serrata (Lam.) Killick leaves [55] Methanol extract of Myrica gale L. seeds [54] Cryptostrobin (31) Dichloromethane extract of Morella serrata (Lam.)…”

Section: Other Phytochemicals Identified In Morella and Myrica Speciesmentioning

confidence: 99%

“…Killick leaves [55] Methanol extract of Myrica gale L. seeds [54] Cryptostrobin (31) Dichloromethane extract of Morella serrata (Lam.) Killick leaves [55] Demethoximatteucinol-7methoxy (32) Methanol extract of Myrica gale L. seeds [54] Methanol extract of Myrica gale L. seeds [54] Gallocatechin-4-α-8epicatechin (34) Aerial parts of Myrica gale L. [80] Gallocatechin-4-α-8epigallocatechin (35) Aerial parts of Myrica gale L. [80] Adenodimerin B (36) Methanol extract of Morella adenophora (Hance) J. Herb. roots [19] Adenodimerin C (37) Methanol extract of Morella adenophora (Hance) J. Herb.…”

Section: Other Phytochemicals Identified In Morella and Myrica Speciesmentioning

confidence: 99%

“…Additionally, myricanol shows neuroprotective effects in N2a neuronal cells exposed to H 2 O 2 [ 32 ]. Pretreatment with 0.84 mM of 4 increased 80% of cell viability, decreased 40% of intracellular reactive oxygen species (ROS) formation and reduced intracellular calcium concentrations, compared with the H 2 O 2 group.…”

Section: Biological Activities Exhibited By Secondary Metabolites mentioning

confidence: 99%

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Phytochemicals with Added Value from Morella and Myrica Species

et al. 2020

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Terrestrial plants, due to their sessile nature, are highly exposed to environmental pressure and therefore need to produce very effective molecules that enable them to survive all the threats. Myrica and Morella (Myricaceae) are taxonomically close genera, which include species of trees or shrubs with edible fruits that exhibit relevant uses in traditional medicine. For instance, in Chinese or Japanese folk medicine, they are used to treat diarrhea, digestive problems, headache, burns, and skin diseases. A wide array of compounds isolated from different parts of Myrica and/or Morella species possess several biological activities, like anticancer, antidiabetic, anti-obesity, and cardio-/neuro-/hepatoprotective activities, both in vitro and in vivo, with myricanol, myricitrin, quercitrin, and betulin being the most promising. There are still many other compounds isolated from both genera whose biological activities have not been evaluated, which represents an excellent opportunity to discover new applications for those compounds and valorize Morella/Myrica species.

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“…Neuroprotective effects [32] 80% increase in N2a cells viability treated with 0.84 mM and 100 mM H2O2…”

Section: In Vitro Activitiesmentioning

confidence: 99%

Section: In Vitro Activitiesmentioning

confidence: 99%

Section: Other Phytochemicals Identified In Morella and Myrica Speciesmentioning

confidence: 99%

“…Killick leaves [55] Methanol extract of Myrica gale L. seeds [54] Cryptostrobin (31) Dichloromethane extract of Morella serrata (Lam.) Killick leaves [55] Demethoximatteucinol-7methoxy (32) Methanol extract of Myrica gale L. seeds [54] Methanol extract of Myrica gale L. seeds [54] Gallocatechin-4-α-8epicatechin (34) Aerial parts of Myrica gale L. [80] Gallocatechin-4-α-8epigallocatechin (35) Aerial parts of Myrica gale L. [80] Adenodimerin B (36) Methanol extract of Morella adenophora (Hance) J. Herb. roots [19] Adenodimerin C (37) Methanol extract of Morella adenophora (Hance) J. Herb.…”

Section: Other Phytochemicals Identified In Morella and Myrica Speciesmentioning

confidence: 99%

Section: Biological Activities Exhibited By Secondary Metabolites mentioning

confidence: 99%

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Phytochemicals with Added Value from Morella and Myrica Species

et al. 2020

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Rapid qualitative profiling and quantitative analysis of Juglandis Mandshuricae Cortex and seven flavonoids by ultra‐high performance liquid chromatography–quadrupole/orbitrap high‐resolution mass spectrometry

Sun

Zhao

Zuo

et al. 2021

J of Separation Science

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Juglandis Mandshuricae Cortex is the bark of Juglans mandshurica Maxim., which has been used as a folk medicine plant in China and India. In this study, an ultra-high performance liquid chromatography-quadrupole/orbitrap highresolution mass spectrometry method was developed to clarify and quantify the chemical profiling of Juglandis Mandshuricae Cortex rapidly. A total of 113 compounds were characterized. Among them, seven flavonoids were simultaneously quantified in 15 min, including myricetin, myricetrin, taxifolin, kaempferol, quercetin, quercitrin, and naringenin. The method was validated for accuracy, precision, and the limits of detection and quantification. All calibration curves showed a good linear relationship (r > 0.9990) within test ranges. The intra-and inter-day relative standard deviations were less than 2.16%. Accuracy validation showed that the recovery was between 95.6 and 101.3% with relative standard deviation values below 2.85%. The validated method was successfully applied to determine the contents of seven flavones in Juglandis Mandshuricae Cortex from seven sources and the contents of these places were calculated respectively. This method provides a theoretical basis for further developing the medicinal value of Juglandis Mandshuricae Cortex.

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