Study on Clinical Profile, Complications and Outcome of Copper Sulphate Poisoning at a Tertiary Care Centre in South India

Perumal, Vasanthi; Narayanan, Namitha; Mohanan, Jagadeshan; Rangarajan, Jayanthi; Kalifa, Mohamed; Perincheri, Uma Maheshwari; Palanisamy, Elangumanan; Selvaraj, P.

doi:10.14260/jemds/2016/794

jemds

2016

DOI: 10.14260/jemds/2016/794

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Study on Clinical Profile, Complications and Outcome of Copper Sulphate Poisoning at a Tertiary Care Centre in South India

Vasanthi Perumal¹,

Namitha Narayanan²,

Jagadeshan Mohanan³

et al.

Abstract: BACKGROUNDCopper Sulphate ingestion is a relatively common method of committing suicide in South India. It can be life-threatening with high mortality due to its deleterious effects on upper GIT, kidney, liver and blood.

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Cited by 2 publications

References 13 publications

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Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies

Fontes,

Jauch,

Sailer

et al. 2024

IJMS

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Essential transition metals have key roles in oxygen transport, neurotransmitter synthesis, nucleic acid repair, cellular structure maintenance and stability, oxidative phosphorylation, and metabolism. The balance between metal deficiency and excess is typically ensured by several extracellular and intracellular mechanisms involved in uptake, distribution, and excretion. However, provoked by either intrinsic or extrinsic factors, excess iron, zinc, copper, or manganese can lead to cellular damage upon chronic or acute exposure, frequently attributed to oxidative stress. Intracellularly, mitochondria are the organelles that require the tightest control concerning reactive oxygen species production, which inevitably leaves them to be one of the most vulnerable targets of metal toxicity. Current therapies to counteract metal overload are focused on chelators, which often cause secondary effects decreasing patients’ quality of life. New therapeutic options based on synthetic or natural antioxidants have proven positive effects against metal intoxication. In this review, we briefly address the cellular metabolism of transition metals, consequences of their overload, and current therapies, followed by their potential role in inducing oxidative stress and remedies thereof.

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Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies

Fontes,

Jauch,

Sailer

et al. 2024

IJMS

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A Study of Human Carcinoembryonic Antigen as a Biomarker for Assessing the Severity of Stroke

Krishnamurthy

Srinivas

Jayaram³

et al. 2021

APIK Journal of Internal Medicine

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Background and Objectives: Human carcinoembryonic antigen (CEA) is widely used as a tumor marker. Striking similarities have been reported between process of tumor genesis and atherosclerotic diseases. CEA levels have also been associated with development of atherosclerosis; there are not many studies on the use of CEA as a biomarker in prognostication of stroke. This study was aimed at evaluating the role of CEA as a marker of severity and as a prognostic marker in patients with acute ischemic stroke. Materials and Methods: A hospital-based case–control study was conducted at a tertiary care hospital in Bangalore. Sixty-eight individuals above 18 years of age were divided into two groups with 34 individuals each: Group A (ischemic stroke) and Group B (age- and sex-matched healthy controls). Exclusion criteria for Group A included diabetes mellitus, heavy smoking, and recent cerebrovascular or myocardial events. The blood sample was taken not later than 24 h of onset of stroke in Group A. CEA levels were estimated using double-sandwich ELISA method. CEA was compared in both the groups. Data were analyzed using statistical software SPSS version 21. Results: The mean standard error serum CEA levels in ischemic stroke patients (cases) and healthy controls were 5.67 ± 1.64 and 0.973 ± 0.21 ng/mL, respectively (P < 0.001). This was significant even after adjusting for confounders. The cases were further divided into three quartiles based on CEA levels. The mean duration of hospital stay, mortality and higher National Institutes of Health Stroke Scale scores, and poor improvement in grade of power were seen in cases under higher CEA quartile (>7 ng/ml) group. The difference was statistically significant. Conclusion: Patients with ischemic stroke have raised level of CEA. CEA is a promising novel biomarker for assessing the severity of acute ischemic stroke.

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Study on Clinical Profile, Complications and Outcome of Copper Sulphate Poisoning at a Tertiary Care Centre in South India

Abstract: BACKGROUNDCopper Sulphate ingestion is a relatively common method of committing suicide in South India. It can be life-threatening with high mortality due to its deleterious effects on upper GIT, kidney, liver and blood.

Cited by 2 publications

References 13 publications

Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies

Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies

A Study of Human Carcinoembryonic Antigen as a Biomarker for Assessing the Severity of Stroke

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