Study on combination therapy for lung cancer through pemetrexed‐loaded mesoporous polydopamine nanoparticles

Abstract

Lung cancer is one of the most commonly diagnosed cancers, and surgical resection is the optimal choice for the primary lung tumor. But for the secondary lung cancer, chemotherapy and combined radiotherapy still are the main strategies. To realize the combined treatment for non-small cell lung cancer (NSCLC), in this work, a nanoplatform based on pemetrexed (PE)-loaded mesoporous polydopamine (MPDA) nanoparticles were investigated. PE, a special therapeutic drug for NSCLC, was loaded into the MPDA nanoparticles via electrostatic attraction and was encapsulated with polyvinyl pyrrolidone (PVP). The results showed that, when irradiating with 808 nm nearinfrared light, the PE loaded MPDA (MPDA@PE@PVP) nanoparticles have excellent photothermal conversion properties, which would result in increase of ambient temperature and could accelerate the release of PE. In vitro cell experiments proved that MPDA@PE@PVP nanoparticles have excellent killing ability for NSCLC A549 cells by the functions of PE and photothermal ability of MPDA nanoparticles. Meanwhile, the intra-cellular reactive oxygen species (ROS) levels of A549 cells in the MPDA@-PE@PVP nanoparticle-treated group could be promoted significantly after irradiation, leading to the death of A549 cells. In vivo animal model results showed that MPDA@PE@PVP nanoparticles could gather at the tumor site by enhanced permeability and retention (EPR) effect and have significant inhibition ability for lung tumor by synergistic therapy of chemotherapy, photothermal therapy and photodynamic therapy.

Clinical Practice of Photodynamic Therapy for Non-Small Cell Lung Cancer in Different Scenarios: Who Is the Better Candidate?

“…Increasing evidence has highlighted the role of chemo-photodynamic combinatorial therapy in lung cancer and metastatic sites. PDT and chemotherapy can be delivered simultaneously with chlorin e6 and doxorubicin-loaded with mesoporous silica nanoparticles [75], and pemetrexed loaded with mesoporous polydopamine nanoparticles [76]. The chlorin e6 and cisplatin drugs modified with the mMnO2-coated UCNPs and tumor-targeting pentapeptide were successfully used to treat spinal metastasis of NSCLC [77].…”

Advancements in Laser and Ultrasound Therapeutic Strategies for Cancer Cells: Recent Review

“…For instance, laser therapy, also known as phototherapy or photobiomodulation, utilizes specific wavelengths of light to induce biochemical changes within cells [7]. In addition to its direct effects on cancer cells, laser therapy can enhance the efficacy of other treatment modalities when combined with chemotherapy, significantly reducing tumor size [8,9].…”