Study on Correlation of Serum Ferritin With Glycosylated Hemoglobin in Type 2 Diabetes Mellitus Patients

Abstract

Introduction: Diabetes mellitus is one of the leading cause of mortality and morbidity worldwide. Type 2 DM is a complex group of disorders characterized by different levels of insulin resistance, impaired secretion of insulin , and increased production of glucose. The complications of diabetes mellitus are inuenced by the average level of blood glucose along with glycosylated hemoglobin. Serum ferritin is an indicator of iron store. Iron stores are associated with decrease in insulin sensitivity, insulin secretion and hence type 2 diabetes. Methods: This study was done in Department of Biochemistry in collaboration with Medicine Department of Gandhi medical college Bhopal. 160 previously diagnosed type 2 diabetes subjects (mean age 55.59±7.74 years) with mean BMI 30.14±3.48kg/m2 were taken and their Serum ferritin, Fasting Blood Sugar and Glycosylated Hemoglobin were measured. Results: It was found that serum ferritin was signicantly high in diabetic patients and serum ferritin had a positive correlation with increasing glycosylated hemoglobin and Fasting blood sugar. Conclusion:It was concluded that serum ferritin level can be used as an indicator of control of glycaemia in type 2 diabetes mellitus patients. HbA1C and Serum ferritin level can also be used as a marker to prevent complications of the disease.