Study on Diagnostic Modalities in Smear Negative Pulmonary Tuberculosis With Special Reference to Sputum Induction (Si Cbnaat), Bronchoscopy (Bal Cbnaat and Bal Culture)

Mohanty, Thitta; Panigrahi, Santosh Kumar; Pattnaik, Manoranjan; Panda, Geetanjali; Routray, Deepwanweta; Patra, Jeetendra Kumar; Meher, Bijaya Kumar

doi:10.18410/jebmh/2017/567

Cited by 5 publications

(3 citation statements)

References 8 publications

(11 reference statements)

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“…In a study conducted by Mohanty T et al 12 shows out of 71 patients who were smear AFB-negative cases, sputum for CBNAAT was positive in 23 (32%) patients, which correlates with our study, out of 80 sputum AFB-negative samples 29 (36%) were CBNAAT positive and rest were negative. Incidence was more in diabetics, i.e.…”

Section: Discussionsupporting

confidence: 91%

Efficacy of Cb-Naat in Detecting Sputum Negative Pulmonary Tuberculosis

K.N¹,

Vinod²,

Ishwarappagol³

et al. 2017

jebmh

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BACKGROUND Tuberculosis (TB) is a major health problem in India. The World Health Organization has recently in 2010 endorsed the GeneXpert MTB/RIF assay for rapid detection of smear negative and multidrug-resistant tuberculosis. The aim of the study is to evaluate the role of Cartridge-Based Nucleic Acid Amplification Test (CBNAAT) in sputum AFB negative Pulmonary Tuberculosis (PTB). MATERIALS AND METHODS This is an observational study conducted in the Department of Pulmonary Medicine, RRMCH, Bengaluru, between August 2016 to June 2017. Patients who presented with symptoms and signs suggestive of pulmonary tuberculosis, chest x-ray showing features of pulmonary tuberculosis were included in the study whose sputum for AFB was negative. Sputum/BAL samples from these patients were sent for CBNAAT. RESULTS CBNAAT was done for 80 samples of the patients who were having history and CXR suggestive of pulmonary tuberculosis with sputum AFB negative. Out of these 80 sputum-AFB negative samples, 29 (36%) were CBNAAT positive. Most of the cases were men aged >50 yrs. Most diabetics (78%) were CBNAAT positive. Most diabetics had HbA1C >10. Most diabetics had lower zone infiltrates on CXR. CONCLUSION Because of its simplicity, rapidity and sensitivity, this seems to be a very novel tool for diagnosis of extrapulmonary tuberculosis from clinical samples and that it should be researched more thoroughly.

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Section: Discussionsupporting

confidence: 91%

Efficacy of Cb-Naat in Detecting Sputum Negative Pulmonary Tuberculosis

K.N¹,

Vinod²,

Ishwarappagol³

et al. 2017

jebmh

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“…In this study sensitivity of CBNAAT varied significantly between 100% in sputum smear-positive PTB and 22.6% in sputum smear negative PTB. Saugat et al 8 and Mohanty T et al 9 .,reported sensitivity of 15% and 32% of CBNAAT in smear negative PTB, which correlates with the present study.…”

Section: Discussionsupporting

confidence: 90%

DIAGNOSTIC PERFORMANCE OF ZIEHL-NEELSEN & CBNAAT TECHNIQUES IN PULMONARY TUBERCULOSIS, A RETROSPECTIVE ANALYSIS AT TERTIARY CARE HOSPITAL IN JHALAWAR, RAJASTHAN.

Hora¹,

Raman²,

Kumar³

et al. 2021

IJMBS

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Introduction: Tuberculosis (TB) remains a leading cause of death among infectious diseases worldwide. The advent of the CBNAAT was a revolution in the diagnosis of tuberculosis, especially with high incidence and resource poor regions. It can be used close to the point of care by operators with minimal technical expertise, enabling diagnosis of TB and rifampicin Resistance (RIF) concurrently using unprocessed clinical specimens, in less than 2h. Aim: To evaluate the diagnostic performances of Ziehl-Neelsen & CBNAAT techniques in detection of Pulmonary Tuberculosis. Materials and Methods: We retrospectively reviewed the 2414 sputum samples of suspected pulmonary TB. Sputum samples were subjected for ZN staining and CBNAAT.RIF resistance was detected by CBNAAT. Results: Out of 2414 samples, 751 sputum samples were positive by smear microscopy. 1127 Samples were confirmed positive by CBNAAT examination. Majority of cases, 43.57% were in 21-40 yrs age group.24.40% were females and 75.59% were males. Sensitivity of CBNAAT was 100% for sputum positive cases and sensitivity was 22.6% for sputum negative cases. Overall RIF resistance was detected in 49 (4.4%) cases in present study. Conclusion: CBNAAT provide sensitive detection of tuberculosis and rifampicin resistance directly from untreated sputum in less than 2 hours with minimal hands-on time. Keywords: Cartridge-based nucleic acid amplification tests (CBNAAT), Rifampicin(RIF)

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“…Sharma (New Delhi, India) described that Xpert has 77.7% sensitivity for smear negative and culture positive TB in comparison to 99.2% for smear and culture positive TB [28]. In the study of Mohanty (Cuttack, India)(April 2016 to March 2017), with culture as gold standard, sensitivity, specificity, positive predictive value(PPV) and negative predictive value(NPV) of sputum induction CBNAAT were 61.9%, 96.5%, 96.3%, 63.6%, respectively and of BAL CBNAAT were 88.09%, 96.5%, 97.36%, 84.84%, respectively [29]. Agrawal (Delhi, India, Jan 2015 to Nov 2015) demonstrated that using culture as reference, sensitivity, specificity, PPV and NPV of CBNAAT were 86.8%, 93.1%, 78.5% and 96% respectively [19].…”

Section: Discussionmentioning

confidence: 99%