In the entire wind turbine system, the blade acts as the central load-bearing element, with its stability and reliability being essential for the safe and effective operation of the wind power unit. Carbon fiber, known for its high strength-to-weight ratio, high modulus, and lightweight characteristics, is extensively utilized in blade manufacturing due to its superior attributes. Despite these advantages, carbon fiber composites are frequently subjected to cyclic loading, which often results in fatigue issues. The presence of internal manufacturing defects further intensifies these fatigue challenges. Considering this, the current study focuses on carbon fiber composites with multiple pre-existing cracks, conducting both static and fatigue experiments by varying the crack length, the angle between cracks, and the distance among them to understand their influence on the fatigue life under various conditions. Furthermore, this study leverages the advantages of Paris theory combined with the Extended Finite Element Method (XFEM) to simulate cracks of arbitrary shapes, introducing a fatigue simulation method for carbon fiber composite laminates with multiple cracks to analyze their fatigue characteristics. Concurrently, the Particle Swarm Optimization (PSO) algorithm is employed to determine the optimal weight configuration, and the Backpropagation neural network (BP) is used to train and adjust the weights and thresholds to minimize network errors. Building on this foundation, a surrogate model for predicting the fatigue life of carbon fiber composite laminates with multiple cracks under conditions of physical parameter uncertainty has been constructed, achieving modeling and assessment of fatigue reliability. This research offers theoretical insights and methodological guidance for the utilization of carbon fiber-reinforced composites in wind turbine blade applications.