Study on Host-Related Factors Affecting Gastric Cancers

Abstract

A study was conducted to investigate cellular immunity as a host-related factor affecting gastric cancer. The relationship between cellular immunity and therapeutic efficacy was examined in patients with gastric cancer treated by curative resection, in order to determine the immunological condition of the hosts for which BRM therapy would be maximally effective. The results of the treatment were favorable in patients who were preoperatively negative for serum LAP and positive for the PPD skin test. Thus the efficacy of BRM therapy seems to be predictable on the basis of these two parameters. Variations in the response to the Su-PS skin test reflected the results of the treatment. Therefore these variations are particularly useful for predicting the efficacy of BRM therapy using OK-432. Thus, screening for BRM therapy on the basis of cellular immunity seems to be possible if appropriate parameters are used.