Study on medication rules of modern chinese herbal medicine in the treatment of non-small cell lung cancer based on data mining

Liu, Liting; Zhao, Cuiyun; Wu, Tong Tong; Yu, Ziyang; Sun, Yongkang; Li, Jie

doi:10.4103/wjtcm.wjtcm_36_19

Cited by 14 publications

(12 citation statements)

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“…Traditional chemotherapy drugs are often difficult to exert their efficacy because of the existence of the blood-brain barrier and tumor self-protection mechanism. Conventional radiotherapy has a low therapeutic effect due to insufficient local radiotherapy dose [ 12 ]. Therefore, there is an urgent need for new clinical treatments to control the progress of tumors.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Immunotherapy Combined with Radiotherapy in Patients with Brain Metastasis of Driver Gene-Negative Non-Small-Cell Lung Cancer

Zhcang

Zhou

Yin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Purpose. To observe the remission rate and side effects of immunotherapy combined with radiotherapy in patients with brain metastasis of driver gene-negative non-small-cell lung cancer (NSCLC). Methods. 152 patients with NSCLC brain metastasis admitted to our hospital from January 2019 to December 2021 were selected as the research objects. Patients were divided into a single group (85 cases) and a combined group (67 cases) according to treatment methods. The therapeutic effects and side effects of the single group and combined group were compared. In addition, the patients who received immunotherapy combined with radiotherapy were divided into three subgroups: A, B, and C, and the therapeutic effects and side effects of different radiotherapy modes were compared among group A [whole brain radiotherapy (WBRT)], group B (WBRT combined with local radiotherapy) and group C (local radiotherapy). Results. The objective response rate (ORR) and disease control rate (DCR) in the combined group were higher than those in the single group ( P < 0.05 ). The incidence of reactive capillary hyperplasia and immune-related pneumonia in the combined group were higher than that in the single group ( P < 0.05 ). There was no significant difference in the incidence of other side effects between the two groups ( P > 0.05 ). ORR and DCR in group B were higher than those in group A ( P < 0.05 ). There was no significant difference in the incidence of side effects among the three groups ( P > 0.05 ). Conclusion. Immunotherapy combined with radiotherapy is effective in patients with brain metastasis of driver gene-negative NSCLC, which can improve the disease control rate without increasing the side effects. In addition, WBRT combined with local push radiotherapy is effective and safe. Clinical Study Registration Number. The Clinical study registration number is K2019086.

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Section: Discussionmentioning

confidence: 99%

Analysis of Immunotherapy Combined with Radiotherapy in Patients with Brain Metastasis of Driver Gene-Negative Non-Small-Cell Lung Cancer

Zhcang

Zhou

Yin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Individual‐level factors such as age [21–26], gender [23, 27, 28], ethnicity [29, 30], migration status [30–33], marital status [22, 26, 32, 34], level of education [22, 26, 31, 34], income [34, 35], employment status [36, 37], personal health [23, 29, 38, 39], knowledge of HIV/ART [27, 30, 33, 35, 36, 38–48], as well as HIV infection factors such as duration of HIV diagnosis [26,29,32,49] were considered to be factors driving healthcare utilization. Older individuals may be less likely to receive ART due to limited mobility and financial difficulties [32], and there is evidence to show that age‐related memory loss may also lead to poor adherence to one's ART drug regimen [35].…”

Section: Resultsmentioning

confidence: 99%

“…PLWH who perceived their health status as good [22, 24, 29, 39, 40, 52] or having comorbidities [38] tended to refuse or discontinue ART. Working outside of their home town [26, 27, 34, 50], forgetfulness [34, 50, 53], side effects of antiretroviral drugs [22, 26–28, 34, 35, 39–42, 50, 52–54], lack of time [34, 44], busy work schedules [25,27,28] and recreational drug use [27, 50, 53] were also common challenges to daily ART adherence. Conversely, ART education training [26, 27] and HIV volunteer training [28] can reduce the risk of non‐compliance.…”

Section: Resultsmentioning

confidence: 99%

Disparities in healthcare access and utilization among people living with HIV in China: A scoping review and meta‐analysis

et al. 2023

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BackgroundThis review aims to assess the status of healthcare disparities among people living with HIV (PLWH) in China and summarize the factors that drive them.MethodsWe searched PubMed, Web of Science, Cochrane Library, Scopus, China National Knowledge Infrastructure (CNKI) and China Wanfang for studies published in English or Chinese. Studies focusing on any disparities in healthcare services among PLWH in China and published between January 2000 and July 2022 were included.ResultsIn all, 51 articles met the inclusion criteria, with 37 studies reporting HIV‐focused care, and 14 reporting non‐HIV‐focused care. PLWH aged ≥45 years (vs. <45 years), female (vs. male), ethnic minority (vs. Han), and cases attributed to sexual transmission (vs. injecting drug use) were more likely to receive ART. Females living with HIV have higher ART adherence than males. Notably, 20% [95% confidence interval (CI): 9–43%, I2 = 96%] of PLWH reported any illness in the previous 2 weeks without medical consultation, and 30% (95% CI: 12–74%, I2 = 90%) refused hospitalization when needed in the previous year. Barriers to HIV‐focused care included inadequate HIV/ART knowledge and treatment side effects at the individual level; and social discrimination and physician–patient relationships at the community/social level. Structural barriers included medical costs and transportation issues. The most frequently reported barriers to non‐HIV‐focused care were financial constraints and the perceived need for medical services at individual‐level factors; and discrimination from physicians, and medical distrust at the community/social level.ConclusionThis review suggests disparities in access and utilization of healthcare among PLWH. Financial issues and social discrimination were prominent reasons. Creating a supportive social environment and expanding insurance policies could be considered to promote healthcare equity.

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“…The presence of pharmacological compounds such as sinomenine in herbal plants exhibits few side effects as compared to the therapeutic agents used in the West. This approach has garnered the attention of scientists and researchers towards TCM for the exploration of their advantages for the development of therapeutic healthcare 14,15 . Since its introduction as a systems-biology application, network pharmacology is regarded as a potential aspect of predicting drugs and their related target proteins 16 .…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacological Investigation of Sinomenine Action Against Synovitis

Li¹,

Mao²,

Zhou³

et al. 2022

International J. of Pharmacology

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Background and Objective: Synovitis is characterized as the inflammation of the synovial membrane, which often occurs in osteoarthritis.The incidence of this medical condition may be related to age, immunological responses and other co-morbidities. Therefore, the objective of the study was to elucidate the anti-Synovitis potential of sinomenine. Materials and Methods: The associated targets about sinomenine and synovitis were investigated in Homo sapiens, which was then elucidated by the PPI network construction via STITCH database. Furthermore, Cytoscape and its plugin were used for gene ontology (GO) analysis. Results: The literature survey and the network revealed 25 potential target proteins to be associated with sinomenine, of which many proteins such as OPRD1, CHRM1 and DAMGO were found to be significantly related to the bioactive action of sinomenine in Homo sapiens. Moreover, the GO terms which were associated with the functioning of sinomenine for its anti-Synovitis potential were found to be four, analyzed by the functional annotation gene clusters and abundance values of the target proteins. Conclusion: The results of the study demonstrate the anti-Synovitis potential of sinomenine, where its action is dependent upon the molecular mechanisms that exert its beneficial role against synovitis. The core mechanisms that may be related to its anti-synovitis action may be adenylate cyclase-activating G-protein coupled receptor signalling pathway, regulation of smooth muscle contraction, adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signalling pathway and positive regulation of nitric oxide metabolic process.

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Study on medication rules of modern chinese herbal medicine in the treatment of non-small cell lung cancer based on data mining

Cited by 14 publications

References 0 publications

Analysis of Immunotherapy Combined with Radiotherapy in Patients with Brain Metastasis of Driver Gene-Negative Non-Small-Cell Lung Cancer

Analysis of Immunotherapy Combined with Radiotherapy in Patients with Brain Metastasis of Driver Gene-Negative Non-Small-Cell Lung Cancer

Disparities in healthcare access and utilization among people living with HIV in China: A scoping review and meta‐analysis

Network Pharmacological Investigation of Sinomenine Action Against Synovitis

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