Study on Photodynamic Therapy for HL60 Cells Inactivation by Visible Light-Induced Fe-Doped Nano-TiO₂ under Magnetic Field

Abstract

Fe-doped TiO2 was prepared by a homogenous precipitation method and characterized by XRD, UV-Vis DRS. The structure and the optical properties of nano-TiO2 with different Fe doping content were studied, as well as the effect and the possible mechanics of different intensity of TiO2 particles, Fe-doped nano-TiO2 particles on the activity of HL60 leukemic cells. The influence on the activity of cells exposures in light compared with un-exposure also be analysed. As the photo sensitizers, TiO2 and Fe-doped TiO2 particles eliminated tumor cell using photodynamic therapy(PDT)under magnetic field.

Physical energy for drug delivery; poration, concentration and activation

“…An increased uptake of cytotoxic agents and magneto-cell lysis producing mechanical tumor ablation is speculated. For instance, the effect of TiO 2 and Fe-doped TiO 2 MNP on the activity of HL60 leukemic cells was studied by observing the influence on the activity of cells exposed to light compared to un-exposure [70]. It was observed that the PS (TiO 2 ) completely eliminated tumor cells using illumination under an applied magnetic field..…”