Study on Platelet Indices in Pregnancy Induced Hypertension

Siddiqui, Rabia; Chandrakar, Kajal; Varma, Ruchi; Shrivastava, Shruti

doi:10.18410/jebmh/2015/1079

Cited by 10 publications

(15 citation statements)

References 1 publication

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“…In our study mean Platelet count is 1.8 lakhs in preeclampsia which is comparable with Mohapatra et al who observed platelet count as 1.8 lakhs & Vrunda et al who observed the value of Platelet count as 1.4 in preeclampsia [5][6][7][8] In our study MPV in preeclampsia which is comparable with Giles et al who observed MPV of 9.9, Annam et al observed the value of MPV as 10.3 in preeclampsia [5][6][7][8].…”

Section: Discussionsupporting

confidence: 89%

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Study of Platelet Indices in Pregnancy Induced Hypertension

Balaji¹,

Teja²,

Govindraj³

et al. 2020

SJAMS

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Section: Discussionsupporting

confidence: 89%

“…Recent studies suggest that platelet parameters like platelet indices are most simple and cost effective methods for prediction of PIH, way before the Medicine appearance of derangements in PT, APTT, TT values [5].…”

Section: Introductionmentioning

confidence: 99%

Study of Platelet Indices in Pregnancy Induced Hypertension

Balaji¹,

Teja²,

Govindraj³

et al. 2020

SJAMS

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“…10 Similar results were revealed in a study done by Siddiqui et al on 125 cases. 9 So in our study we found that MPD increased with increasing severity of PIH. Mean platelet distribution increases in normal pregnancy but non-significantly till 32 weeks while in PIH patients MPD values were higher with increasing severity of hypertension.…”

Section: Discussionsupporting

confidence: 53%

Assessment of platelet indices in pregnancy induced hypertensive patients versus normotensive pregnant patients

Shekhawat¹,

Shrivastava²

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Hypertensive disorders of pregnancy (HDP) represent a group of conditions associated with high blood pressure during pregnancy, proteinuria and in some cases convulsions. The most serious consequences for the mother and the baby result from pre-eclampsia and eclampsia. These are associated with vasospasm, pathologic vascular lesions in multiple organ systems, increased platelet activation and subsequent activation of the coagulation system in the micro-vasculature. It is a multisystem disease and many theories are proposed for pathophysiology. So there is a constant search for better prognostic factors to predict the progression and severity of disease. The fall in platelet count is most frequently found in preeclampsia and is probably due to consumption during low grade intravascular coagulation. The major adverse outcomes of pre-eclampsia and eclampsia include central nervous system injuries such as seizures (eclampsia), ischemic heart disease, stroke, type II diabetes, and venous thromboembolism hemorrhagic and ischemic strokes, hepatic damage, HELLP syndrome, renal dysfunction as well as increased frequency of cesarean delivery, preterm delivery, and abruptio placenta, in comparison with women without history of the disease.Methods: Total 100 subjects, 50 control and 50 cases were taken for study. Samples for platelet count were collected and estimation was carried out by the auto-analyzers. The statistical evaluation is done using SPSS version 22 along with Anova and student t-test.Results: There was a significant difference in platelet count in patients with preeclampsia as compared to control group. Mean platelet diameter was significantly increased in cases with preeclampsia.Conclusions: Thrombocytopenia is directly proportional to the severity of PIH. Platelet count less than 1 lakh/cumm indicate increasing risk of DIC and HELLP syndrome. In this study we noted significant association was established when the platelet counts of PIH cases were compared with the normotensive control patients. Strong association was made out between the platelet count and MPD and MPV and the severity of PIH.

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“…17 Similar results were revealed in a study done by Siddiqui et al on 125 cases. 16 MPV showed gradual increase in preeclampsia patients as compared to normotensive subjects. Inter group analysis done by Nooh et al revealed that changes in MPV values in PE-developing women (with and without severe features) were statistically more significant than normotensive pregnant women and this change was noted to start from the 24 th gestational week up to time of delivery (p = 0.003).…”

Section: Discussionmentioning

confidence: 85%

“…6,15 Study done by Siddiqui et al has stated that approximately 50% of preeclampsia cases will develop thrombocytopenia, similar to that in present study 32% of the preeclampsia cases were having thrombocytopenia. 16 Thrombocytopenia in PIH is mostly caused due to increase consumption of platelet may be due to adherence of platelet at the site of damaged vascular endothelium.…”

Section: Discussionmentioning

confidence: 99%

Correlation of platelet indices with severity of pre-eclampsia: a prospective study from central India

Dhakre

Nandmer

Sapkal

2018

Int J Reprod Contracept Obstet Gynecol

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Background: Although it is generally accepted that the haemoglobin concentration decreases and white cell count increases during normal pregnancy, there is less accord regarding changes in platelet indices. Present study was performed to know the relation of platelet indices with normal pregnancy, preeclampsia and severity of pre-eclampsia.Methods: Hundred pregnant women were studied at Department of Obstetrics and Gynaecology, PCMS and RC, Bhopal after dividing them in two Group N (n=50, normal pregnant women) and Group P (n = 50, pre-eclampsia patient). Platelet indices including platelet count mean platelet volume and platelet distribution width were estimated in all the patients. Data were analyzed using IBM SPSS ver. 20 software. Level of significance was assessed at 5%.Results: In Group P [34 (68%)] and Group N [21 (42%)] most of the patients had platelet count of <2 lac respectively. Whereas Group P, 16 (32%) patients had thrombocytopenia (platelet count between 50-1.5 lac) where as in Group N, none of the patients had lower platelet count. Most of the patients (55%) in study cohort had PDW of 15 fl out of that half of the patients in Group N had PWD as 15 fl whereas in Group P 60% had PDW value as 15 fl. Out of 50 preeclampsia patients 24 (48%) were of severe type, out of which 54% had platelet count <1.5 lac, 83% had PDW as 15-16fl, and 54% had MPV in the range of 10-11 fl.Conclusions: Platelet count decreases while MPV and PDW increase as pregnancy advances, and these changes are more pronounced in preeclampsia than normotensive pregnancy.

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Study on Platelet Indices in Pregnancy Induced Hypertension

Cited by 10 publications

References 1 publication

Study of Platelet Indices in Pregnancy Induced Hypertension

Study of Platelet Indices in Pregnancy Induced Hypertension

Assessment of platelet indices in pregnancy induced hypertensive patients versus normotensive pregnant patients

Correlation of platelet indices with severity of pre-eclampsia: a prospective study from central India

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