Study on promoting the regeneration of grafted fat by cell-assisted lipotransfer

Fu, Hongtao; Dong, Shanshan; Li, Kun

doi:10.1016/j.reth.2022.11.008

Cited by 3 publications

(2 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ADSCs-rich fat helps restore tissue vascularization and organ function [124]. Since then, ADSCs have been used to engineer AT and improve outcomes in fat grafting for tissue augmentation [125][126][127][128]. Currently, ADSCs are widely used in breast reconstruction, especially for breast cancer patients [129,130].…”

Section: Regenerative Features and Utility In Tissue Engineeringmentioning

confidence: 99%

Adipose-Derived Stem Cells: Angiogenetic Potential and Utility in Tissue Engineering

Biniazan,

Stoian,

Haykal

2024

IJMS

View full text Add to dashboard Cite

Adipose tissue (AT) is a large and important energy storage organ as well as an endocrine organ with a critical role in many processes. Additionally, AT is an enormous and easily accessible source of multipotent cell types used in our day for all types of tissue regeneration. The ability of adipose-derived stem cells (ADSCs) to differentiate into other types of cells, such as endothelial cells (ECs), vascular smooth muscle cells, or cardiomyocytes, is used in tissue engineering in order to promote/stimulate the process of angiogenesis. Being a key for future successful clinical applications, functional vascular networks in engineered tissue are targeted by numerous in vivo and ex vivo studies. The article reviews the angiogenic potential of ADSCs and explores their capacity in the field of tissue engineering (TE).

show abstract

Section: Regenerative Features and Utility In Tissue Engineeringmentioning

confidence: 99%

Adipose-Derived Stem Cells: Angiogenetic Potential and Utility in Tissue Engineering

Biniazan,

Stoian,

Haykal

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…When these cell cultures (ASC-EGM) were then injected into immunodeficient mice, they produced significantly greater functional vasculature compared to ASCs grown in conventional media [ 101 ]. Co-culturing ASCs with fibroblasts has also been shown to promote mutual proliferation and improve adipogenic differentiation, hemangioendothelial differentiation and proliferation [ 102 ]. Significantly, in animal experiments, the authors also found that the autografted adipose group combined with both ASCs and fibroblasts had the lowest rate of oily cysts and the best volumetric retention rate.…”

Section: Engineering Strategies To Optimize Regenerative Potential Of...mentioning

confidence: 99%

Deconstructing Fat to Reverse Radiation Induced Soft Tissue Fibrosis

2023

View full text Add to dashboard Cite

Adipose tissue is composed of a collection of cells with valuable structural and regenerative function. Taken as an autologous graft, these cells can be used to address soft tissue defects and irregularities, while also providing a reparative effect on the surrounding tissues. Adipose-derived stem or stromal cells are primarily responsible for this regenerative effect through direct differentiation into native cells and via secretion of numerous growth factors and cytokines that stimulate angiogenesis and disrupt pro-inflammatory pathways. Separating adipose tissue into its component parts, i.e., cells, scaffolds and proteins, has provided new regenerative therapies for skin and soft tissue pathology, including that resulting from radiation. Recent studies in both animal models and clinical trials have demonstrated the ability of autologous fat grafting to reverse radiation induced skin fibrosis. An improved understanding of the complex pathologic mechanism of RIF has allowed researchers to harness the specific function of the ASCs to engineer enriched fat graft constructs to improve the therapeutic effect of AFG.

show abstract

NPTX1 Mediates the Facilitating Effects of Hypoxia-Stimulated Human Adipocytes on Adipose-Derived Stem Cell Activation and Autologous Adipose Graft Survival Rate

Tian,

Wang,

Sun

et al. 2024

Aesth Plast Surg

View full text Add to dashboard Cite

Study on promoting the regeneration of grafted fat by cell-assisted lipotransfer

Cited by 3 publications

References 69 publications

Adipose-Derived Stem Cells: Angiogenetic Potential and Utility in Tissue Engineering

Adipose-Derived Stem Cells: Angiogenetic Potential and Utility in Tissue Engineering

Deconstructing Fat to Reverse Radiation Induced Soft Tissue Fibrosis

NPTX1 Mediates the Facilitating Effects of Hypoxia-Stimulated Human Adipocytes on Adipose-Derived Stem Cell Activation and Autologous Adipose Graft Survival Rate

Contact Info

Product

Resources

About