Study on Risk Factors, Clinical and Biochemical Characteristics of Patients With Chronic Pancreatitis

Abstract

Background: Chronic pancreatitis is a chronic, progressive, irreversible benign inflammatory process, resulting in structural changes with disorders of functional exocrine and endocrine parenchyma by a fibrotic and inflammatory tissue. Based on clinical characteristics and morphology to diagnose chronic pancreatitis. Subjects and methods: A cross-sectional study was conducted on 47 patients with chronic pancreatitis diagnosed based on Rosemont Criteria in endoscopic ultrasound. Results: The prevalence of male was higher than female (37/10) and most common in the age group of 41 - 60 about 65.9%. The prevalence of patients with a history of alcohol abuse was highest with 55.3%. The clinical characteristics of patients with chronic pancreatitis: abdominal pain is 100%, nausea and vomiting are 53.1%. The location of pain in the upper abdominal pain is 93.6%. Severe back pain is 21.3%. About biochemical characteristics, an increase of amylase about 57.5%, lipase about 68.1%, diabetes mellitus about 34.1%, cholesterol about 12.8%, triglycerid about 29.8%, LDL-c about 19.2% and HDL-c lower than 0.9 mmol/L about 38.3%. The results showed that the amylase, lipase and LDL-c levels indicated a positive correlation (r = 0.303, r = 0.257 and p < 0.05). Conclusions: Alcohol was the most important risk factors. Abdominal pain was constant while hyperamylasemia was found only in 57.5% patients. Key words: chronic pancreatitis, risk factors