Study on the anti-inflammatory effect of gastric ulcer and analgesic effect of traditional remedy “Sai ho so can thang gia vi” in the experiment

Abstract

Objective: To evaluate the anti-inflammatory effect of gastric ulcer and analgesic effect of traditional remedy “Sai ho so can thang gia vi” in the experiment.Subjects and methods: Studying the anti-inflammatory effect of the extract from the traditional remedy “Sai ho so can thang gia vi” on a model of gastric ulcer induction by Indomethacin in Swiss white mice.Studying the analgesic effect of the extract on the acetic acid-induced colic model in the white rat strain Wistar.Results: This study has shown that the remedy of adding 8g of Chromolaena odorata leaves at a dose of 150mg/kg/day had a protective effect on the gastric mucosa in indomethacin-induced gastric ulcer model in white rats through the following criteria: Reduces the percentage of mice with ulcers compared with the model batch, but the difference is not statistically significant (p>0.05), but it significantly reduces the ulcer index and the percentage of ulcer inhibition (p<0 .05); significantly reduces the damage on the macroscopic and microscopic images of the rat stomach. Traditional remedies at all three dosage levels (30mg/kg/day, 60mg/kg/day and 120mg/kg/day) have analgesic effects on the acetic acid-induced colic model, reducing the number of colic episodes statistically significant compared with the model batch (p<0.05 and p<0.01).Conclusion: The traditional remedy “Sai ho so can thang gia vi” at a dose of 150mg/kg/day showed a protective effect on gastric mucosa in indomethacin-induced gastric ulcer model in white rats and at all three dose levels (30mg/kg/day, 60mg/kg/day and 120mg/kg/day) had analgesic effects on the acetic acid- induced colic model.