Study on the antidepressant effect of panaxynol through the IκB-α/NF-κB signaling pathway to inhibit the excessive activation of BV-2 microglia

The novel anti-neuroinflammatory functional food CCL01, a mixture of Cuscuta seed extracts and Lactobacillus paracasei NK112

“…3 When NF-κB is in an activated state, the NF-κB inhibitor IκB is degraded, and NF-κB transfers from the cytoplasm to the nucleus, which leads to the transcription and expression of inflammatory factors. 28 As shown in our results, CCL01 may inhibit LPS-induced NF-κB activation via IκB inhibition for the regulation of several inflammatory factors (Fig. 4).…”

“…The redox-sensitive transcription factor Nrf2 plays a crucial role in cellular antioxidant defense, and is engaged to inhibit microglia activation by cytoprotective genes such as HO-1. 28,29 Indeed, it has been reported that Nrf2/HO-1 had an antiinflammatory effect on LPS-induced microglia cells via the inhibition of NF-κB. [28][29][30] Thus, we further investigated the expression levels of the proteins Nrf2/HO-1 in BV2 microglia cells when treated with CCL01.…”

“…28,29 Indeed, it has been reported that Nrf2/HO-1 had an antiinflammatory effect on LPS-induced microglia cells via the inhibition of NF-κB. [28][29][30] Thus, we further investigated the expression levels of the proteins Nrf2/HO-1 in BV2 microglia cells when treated with CCL01. The results indicated that CCL01 also activated the Nrf2/HO-1 pathways (Fig.…”

Novel Pharmacological Approaches to the Treatment of Depression

“…Schisandra chinensis [311], helicid [312], panaxynol [313], and safflower extract [314] regulated various factors in the NF-κB and toll-like receptor 4-nucleotide-binding and oligomerization domain-like receptor 3 (NLRP3) signaling pathways. The honey fungus Armillaria mellea [315] reduced TNF-α and IL-1β [316].…”

Non-targeted metabolomic analysis of variation of volatile fractions of ginseng from different habitats by HS-SPME-GC-MS coupled with chemometrics

“…Among them, ginseng volatile oil has multivarious pharmacological effects such as anti-inammatory effects, cough suppression, antifatigue effects, hypolipidemic effects, alcohol detoxication, central nervous system stimulating effects and antitumour activities. 10,11 At present, excessive excavation has exhausted the natural population of ginseng growing in its natural environment to such a degree that this plant variety is now threatened with extinction in some areas. It is necessary to cultivate the most commonly used varieties to guarantee supplies, namely, cultivated ginseng (CG), transplanted ginseng (TG) and mountain cultivated ginseng (MCG).…”