Study on the Antinociceptive Activity and Mechanism of Action of Isolated Saponins from Siolmatra brasiliensis (Cogn.) Baill

Giorno, Thais Biondino Sardella; Santos, Carlos Henrique Corrêa dos; Carvalho, Mário Geraldo de; Silva, Virgínia Cláudia da; Sousa, Paulo Teixeira de; Fernandes, Patrícia Dias; Boylan, Fábio

doi:10.3390/molecules24244584

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…To evaluate the involvement of the cholinergic receptors, mice were pretreated with a muscarinic acetylcholine receptors (mAChRs) antagonist, the atropine (1 mg/kg, i.p.) [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

“…Naloxone (non-selective opioid receptors antagonist [ 57 ]), atropine (non-selective muscarinic receptor antagonist [ 58 ]), glibenclamide (ATP-sensitive K + channels blocker [ 59 , 60 , 61 ]), haloperidol (dopamine receptors antagonist [ 62 ]), and yohimbine (a selective α2-adrenoceptor antagonist [ 63 ]) were used to substantiate the involvement of the opioidergic, cholinergic, ATP-sensitive K + channels, and dopaminergic and adrenergic systems, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Safety Assessment and Pain Relief Properties of Saffron from Taliouine Region (Morocco)

et al. 2022

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Saffron is the most expensive spice in the world. In addition to its culinary utilization, this spice is used for medicinal purposes such as in pain management. In this study, the analgesic activity of Crocus sativus stigma extract (CSSE) was evaluated in rodents and its possible physiological mechanism was elucidated. The anti-nociceptive effect of CSSE was evaluated using three animal models (hot plate, writhing, and formalin tests). The analgesic pathways involved were assessed using various analgesia-mediating receptors antagonists. The oral administration of CSSE, up to 2000 mg/kg, caused no death or changes in the behavior or in the hematological and biochemical blood parameters of treated animals nor in the histological architecture of the animals’ livers and kidneys. CSSE showed a central, dose-dependent, anti-nociceptive effect in response to thermal stimuli; and a peripheral analgesic effect in the test of contortions induced by acetic acid. The dual (central and peripheral) analgesic effect was confirmed by the formalin test. The anti-nociceptive activity of CSSE was totally or partially reversed by the co-administration of receptor antagonists, naloxone, atropine, haloperidol, yohimbine, and glibenclamide. CSSE influenced signal processing, by the modulation of the opioidergic, adrenergic, and muscarinic systems at the peripheral and central levels; and by regulation of the dopaminergic system and control of the opening of the ATP-sensitive K+ channels at the spinal level. The obtained data point to a multimodal mechanism of action for CSSE: An anti-inflammatory effect and a modulation, through different physiological pathways, of the electrical signal generated by the nociceptors. Further clinical trials are required to endorse the potential utilization of Moroccan saffron as a natural painkiller.

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“…To evaluate the involvement of the cholinergic receptors, mice were pretreated with a muscarinic acetylcholine receptors (mAChRs) antagonist, the atropine (1 mg/kg, i.p.) [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Safety Assessment and Pain Relief Properties of Saffron from Taliouine Region (Morocco)

et al. 2022

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“…In addition, these saponins also cause the activation of cholinergic pathways through stimulation of muscarinic receptors M2 and M4 in the dorsal horn of the spinal cord, contributing to the analgesic effect through the activation of inhibitory interneurons, which reduces nociceptive transmission. 94…”

Section: Analgesic Mechanisms Of Natural Com-poundsmentioning

confidence: 99%

Potential Activity of Medicinal Plants as Pain Modulators: A Review

Silva-Correa¹,

Campos-Reyna²,

Torre³

et al. 2021

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This review aims to demonstrate the relevance that medicinal plants and their promising results have in prevention and treatment of pain. The neurophysiological bases of pain have been analyzed and the potential mechanisms of action have been proposed, it has also been determined that the main experimental models used for the evaluation of the analgesic potential are: acetic acid-induced writhing test, formalin test, hot-plate test, capsaicin-induced nociception, cinnamaldehyde-induced nociception, glutamate-induced nociception, tail-flick test and tail immersion test. There are countless medicinal plants with potential analgesic activity, in some of them main responsible compounds for the activity are flavonoids (vitexin, quercetin, naringenin, astragalin, eupatilin), alkaloids (scotanamine B, bullatine A, S-(+)dicentrine, stephalagine, lappaconitine), terpenoids (p-cymene, thymol, menthol, citronellol, myrcene, carvacrol, linalool) and saponins (siolmatroside I, cayaponoside D, cayaponoside B4, cayaponoside A1); however, all studies have only been carried out up to pre-clinical stages. Therefore, it is recommended to carry out kinetic studies of the most remarkable natural compounds, evaluate mixtures of active compounds for diminishing doses to avoide possible side effects, and continue with clinical studies of medicinal plants whose safety has already been reported.

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“…Animals were placed individually in a glass cylinder and were observed for 15 min [(glutamic acid), 6 min (capsaicin (TRPV1) and cinnamaldehyde (TRPA1)] and 20 min [menthol (TRPM8) and acidified saline (ASIC)], according to the procedures previously described with modifications. The amount of time, in seconds, spent licking the injected paw was recorded and was considered indicative of nociception [14,[18][19][20].…”

Section: Locomotor Performancementioning

confidence: 99%

Machaerium hirtum (Vell.) Stellfeld Alleviates Acute Pain and Inflammation: Potential Mechanisms of Action

et al. 2020

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Machaerium hirtum (Vell.) Stellfeld (Fabaceae) known in Brazil as “jacaranda de espinho” or “espinheira santa nativa” is a medicinal plant commonly used in folk medicine to treat ulcers, cough and diarrhea. This study aimed to investigate the anti-inflammatory and antinociceptive effects of hydroalcoholic extracts from M. hirtum twig (HEMh) using in vivo experimental models of nociception through the involvement of transient receptor potential channels, acid-sensing ion channel (ASIC), nitrergic, opioidergic, glutamatergic, and supraspinal pathways. Our results revealed an antinociceptive effect of HEMh mediated by the opioidergic, l-arginine-nitric oxide and glutamate systems, as well as by interactions with TRPA1/ASIC channels. The anti-inflammatory effect of HEMh evaluated with a xylene-induced ear edema and by the involvement of arachidonic acid and prostaglandin E2 (PGE2) showed involvement of the COX pathway, based on observed decreases in PGE2 levels. A phytochemical investigation of the HEMh led to the isolation of α-amyrin, β-amyrin, allantoin, apigenin-7-methoxy-6-C-β-d-glucopyranoside, and apigenin-6-C-β-d-glucopyranosyl-8-C-β-d-xylopyranoside. In conclusion, the acute oral administration of HEMh inhibits the nociceptive behavioral response in animals through the nitrergic, opioid, glutamatergic pathways, and by inhibition of the TRPA1 and ASIC channels, without causing locomotor dysfunction. In addition, its anti-inflammatory effect is associated with the COX pathway and decreased PGE2 levels.

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Study on the Antinociceptive Activity and Mechanism of Action of Isolated Saponins from Siolmatra brasiliensis (Cogn.) Baill

Cited by 8 publications

References 24 publications

Safety Assessment and Pain Relief Properties of Saffron from Taliouine Region (Morocco)

Safety Assessment and Pain Relief Properties of Saffron from Taliouine Region (Morocco)

Potential Activity of Medicinal Plants as Pain Modulators: A Review

Machaerium hirtum (Vell.) Stellfeld Alleviates Acute Pain and Inflammation: Potential Mechanisms of Action

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