Study on the Effect of Humic Acid on Growth Performance, Immunological, Some Blood Parameters and Control Intestinal Closterdium in Broiler Chickens

Salah, Hala; Mansour, Elsayed; Reham, R; Hamid, Eman

doi:10.21608/zvjz.2015.29352

Cited by 17 publications

(14 citation statements)

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“…Bacteria cause lymphocyte stimulation and its differentiation into T and B lymphocytes resulting in increase of globulins levels and acquired immune response. These findings agree with previously published papers [43,44] in which a significant increase in serum levels of and total globulins in Cl. perfringens-infected chickens was noticed.…”

Section: Discussionsupporting

confidence: 94%

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Effect of Experimental Clostridium perfringens Infection on Some Immunological, Hematological and Biochemical Values in Broiler Chickens

Khodary¹,

El-Deen

el-Deen³

2019

Zagazig Veterinary Journal

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This study aimed to demonstrate the effect of Clostridium perfringens (Cl. perfringens) infection on broiler chickens. Also, to compare between the effect of amoxicillin and / or organic acids on Cl. perfringens infection through the evaluation of hemogram, blood chemistry, hepato-renal functions and immune response using ELISA technique. One hundred, one-day old Hubbard chicks were divided into five equal groups. Group 1: negative control, Group 2: infected broilers with Cl. perfringens type A (1.9×10 9 organism/mL), Group 3: infected chickens and treated with amoxicillin [15 mg/kg body weight (B.W.)] for 5 successive days, Group 4: chickens were administered organic acids (1 mL /L water) then were infected and Group 5: infected chickens then treated with both amoxicillin and organic acids. Cl. perfringens infection resulted in decreased appetite, ruffled feathers and brownish diarrhea with sudden death in some cases with a mortality rate up to 25%. Birds infected and treated with amoxicillin showed mild clinical signs with 15% mortalities. Majority of chickens supplemented with organic acids or with organic acids and amoxicillin followed by Cl. perfringens infection showed depression with a mild diarrhea and 10% mortality rate. Chickens infected with Cl. perfringens had macrocytic hypochromic anemia, leukocytosis, heterophilia and monocytosis. In addition, a significant decrease of total protein, albumin, phagocytic % and phagocytic index with a significant increase of total golbulins, liver enzymes activities, serum uric acid, creatinine and glucose levels were reported. Treatment of Cl. perfringens infection with amoxicillin, organic acids alone or their combination resulted in a positive effect in treatment, ameliorating the severity of infection and a significant improvement in some immunological and biochemical parameters. In conclusion, the combination of amoxicillin and organic acids showed the best results as it returned all hematological, biochemical and immunological parameters to their normal levels.

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Section: Discussionsupporting

confidence: 94%

“…IgM and IgG isotypes are indicators for resistance of diseases in poultry [48]. Our results agree with Salah et al ., [44] who proved that Cl. perfringens infection in chicken resulted in a decrease of phagocytic index and phagocytic %.…”

mentioning

confidence: 99%

Effect of Experimental Clostridium perfringens Infection on Some Immunological, Hematological and Biochemical Values in Broiler Chickens

Khodary¹,

El-Deen

el-Deen³

2019

Zagazig Veterinary Journal

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“…27 Furthermore, the reduction of mortality rate beside the disappearance of clinical signs and improved body gain in broiler chickens treated with lincomycin were reported. 28 The phagocytosis recorded in the present study after CP inoculation was also recorded previously and same changes in blood picture of the chickens in the current study were reported previously, 3,29 and stated that broilers suffering from NE showed a significant decrease in the total erythrocytic count, hemoglobin content, Packed Cell Volume % associated with significant increase leukocytic count, phagocytic activity and phagocytic index all over the experimental period post infection. Similarly, in ducklings suffering from NE, the same alterations in blood picture were reported previously.…”

Section: Discussionsupporting

confidence: 89%

Comparative studies on the efficacy of lincomycin and bacitracin for the control of necrotic enteritis in broiler chickens

Elkomy¹,

Farag²,

Gharbawy³

et al. 2019

Int J Basic Clin Pharmacol

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Background: The present study was conducted to evaluate the efficacy of lincomycin and/or bacitracin for control of experimentally-induced Clostridium perfringens (CP) infection in broiler chickens.Methods: A total of 100 one-day-old Cobb-mixed chicks were divided into five groups (A, B, C, D and E, each of 20 bird). At the 15th day of age, all birds (except group A) were inoculated orally with CP broth culture (109 CFU/mL). Two days later, drugs were orally administered once daily for five consecutive days as follow; Group A and B were left untreated. Group C, D, and E were treated with lincomycin (0.5 g/l), bacitracin (100 mg/l), lincomycin and bacitracin, respectively. The efficacy of used drugs was estimated based on clinical symptoms, body weight, weight gain, feed conversion rate. Hematobiochemical changes were also determined.Results: Necrotic enteritis in broiler chickens induced a significant decrease in body weight, weight gain, erythrocytic count, hemoglobin content, PCV %, serum proteins, catalase, and superoxide dismutase. Additionally, a marked decrease in serum lipids was obtained. Furthermore, a significant increase in feed conversion rate, leukocytic count, phagocytic activity, phagocytic index, serum total globulin, γ globulin and malondialdehyde coupled with a marked increase in β and α globulins were determined. Medication of infected broilers with lincomycin and/or bacitracin improved clinical signs and reduced mortality rate to 8, 6 and 2%, respectively, as well as restored the performance and hematobiochemical alterations.Conclusions: a combination of lincomycin and bacitracin was of considerable value for the control of necrotic enteritis in broiler chickens.

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“…This finding is similar to the conclusion made by Pistová et al (2016) who reported that broiler chickens fed a diet containing 1% of humic acid showed a significantly higher body weight (P < 0.05) in comparison to the control. Furthermore, other studies reported an increase in body weight especially during the last stage of fattening (Karaoglu et al 2004;Ozturk et al 2012;Salah et al 2015). According to Arif et al (2018), the HS forms a protective film on the mucous epithelia of the gastrointestinal tract against infectious/pathogenic agents and toxins, which results in an increased weight gain and final weight of animals.…”

Section: Discussionmentioning

confidence: 90%

“…They have demonstrated a strong affinity to bind various substances, such as heavy metals, mycotoxins, and herbicides (Arafat et al 2017). Including this natural component in the animal diet has been found to positively affect the functions of the immune system (Salah et al 2015), improve gut health (Arif et al 2018), reduce the incidence of diarrhoea and other digestive disorders, as well as to decrease mortality and maintain the standard health status (Nagaraju et al 2014;Khan and Iqbal 2016). They influence the permeability of the cell wall and facilitate the transfer of minerals from blood to bone and cells (Yıldız et al 2013).…”

mentioning

confidence: 99%

The effect of dietary humic substances on the fattening performance, carcass yield, blood biochemistry parameters and bone mineral profile of broiler chickens

Jaďuttová¹,

Marcinčáková²,

Bartkovský³

et al. 2019

Acta Vet. Brno

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Humic substances are currently being considered as a new feed component in replacement of antibiotic growth stimulators to improve growth and health in animals. The aim of our work was to evaluate the effect of the addition of humic substances to the feed at concentrations of 0.8% and 1.0% on the growth parameters, carcass yield, selected blood enzymes, minerals, and the bone quality in broiler chickens. One hundred fifty COBB 500 one-day-old male broiler chicks were randomly divided into one control and two experimental groups (n = 50) with three replications (16, 16 and 17 per pen), and fattened for 35 days. The broilers of the experimental groups (H0.8 and H1.0) were fed commercial feed mixtures with added humic substances (at 8 g·kg-1 and 10 g·kg-1). The control group was fed a diet without the addition of humic substances. A slight increase in the final body weight and feed conversion ratio was noted in the experimental groups (P > 0.05). Significantly higher yields of breast and thigh meat (P < 0.05) were recorded for the experimental group H1.0. The blood cholesterol level was lower for both experimental groups. A lower concentration of alkaline-phosphatase was observed in group H1.0. A decrease in aspartate aminotransferase and calcium was recorded for group H0.8. A significantly higher content of calcium and lower content of phosphorus was found in the bones of experimental animals. The 1% addition of humic substances had a positive impact on growth parameters (P > 0.05), improved selected blood indices and increased the calcium content in the bones of broilers (P < 0.05).

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Study on the Effect of Humic Acid on Growth Performance, Immunological, Some Blood Parameters and Control Intestinal Closterdium in Broiler Chickens

Cited by 17 publications

References 0 publications

Effect of Experimental Clostridium perfringens Infection on Some Immunological, Hematological and Biochemical Values in Broiler Chickens

Effect of Experimental Clostridium perfringens Infection on Some Immunological, Hematological and Biochemical Values in Broiler Chickens

Comparative studies on the efficacy of lincomycin and bacitracin for the control of necrotic enteritis in broiler chickens

The effect of dietary humic substances on the fattening performance, carcass yield, blood biochemistry parameters and bone mineral profile of broiler chickens

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