Study on the formation of DNA adduct 8-hydroxy-2’-deoxyguanosine (8-OHdG) in vitro with bisphenol a through Fenton reaction

Budiawan, B.; Handayani, Sri; Dani, I. C.; Bakri, Ridla; Juniarti, P.; Nahla, N.

doi:10.1063/1.5064053

Cited by 1 publication

(1 citation statement)

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“…In a short report published in conference proceedings, 8‐OHdG was produced in vitro by reacting dG with BPA in the presence of the Fenton reagent. The authors conclude that BPA may act as a pro‐oxidant (Budiawan et al, 2018 [RefID 757‐G]) although the very low levels of 8‐OHdG formation (42.26 ppb, analysed by HPLC/EC) raise questions about the relevance of this short report. Due to their limitations, these two studies are considered of ‘insufficient reliability’, and thus do not allow to conclude on the ability of BPA to induce oxidation of DNA bases.…”

Section: Assessmentmentioning

confidence: 90%

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

Lambré¹,

Baviera²,

Bolognesi³

et al. 2023

EFS2

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In 2015, EFSA established a temporary tolerable daily intake (t‐TDI) for BPA of 4 μg/kg body weight (bw) per day. In 2016, the European Commission mandated EFSA to re‐evaluate the risks to public health from the presence of BPA in foodstuffs and to establish a tolerable daily intake (TDI). For this re‐evaluation, a pre‐established protocol was used that had undergone public consultation. The CEP Panel concluded that it is Unlikely to Very Unlikely that BPA presents a genotoxic hazard through a direct mechanism. Taking into consideration the evidence from animal data and support from human observational studies, the immune system was identified as most sensitive to BPA exposure. An effect on Th17 cells in mice was identified as the critical effect; these cells are pivotal in cellular immune mechanisms and involved in the development of inflammatory conditions, including autoimmunity and lung inflammation. A reference point (RP) of 8.2 ng/kg bw per day, expressed as human equivalent dose, was identified for the critical effect. Uncertainty analysis assessed a probability of 57–73% that the lowest estimated Benchmark Dose (BMD) for other health effects was below the RP based on Th17 cells. In view of this, the CEP Panel judged that an additional uncertainty factor (UF) of 2 was needed for establishing the TDI. Applying an overall UF of 50 to the RP, a TDI of 0.2 ng BPA/kg bw per day was established. Comparison of this TDI with the dietary exposure estimates from the 2015 EFSA opinion showed that both the mean and the 95th percentile dietary exposures in all age groups exceeded the TDI by two to three orders of magnitude. Even considering the uncertainty in the exposure assessment, the exceedance being so large, the CEP Panel concluded that there is a health concern from dietary BPA exposure.

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Section: Assessmentmentioning

confidence: 90%