Study on the levels of trace elements in mild and severe psoriasis

Basavaraj, KH; Darshan, Medha S.; Shanmugavelu, P.; Rashmi, R; Mhatre, Amita; Dhanabal, S P; Rao, K. S.

doi:10.1016/j.cca.2009.04.012

Cited by 37 publications

(40 citation statements)

References 22 publications

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“…The PASI is a useful tool in monitoring response to treatment. There are limited studies to show the role of trace elements in psoriasis [30]. Heavy metals are contained in trace concentrations in the raw materials used to manufacture cement [31].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cadmium, Chromium, Nickel, and Zinc in Biological Samples of Psoriasis Patients Living in Pakistani Cement Factory Area

Afridi

Kazi

et al. 2010

Biol Trace Elem Res

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Psoriasis is a noncontiguous common and chronic skin disorder. The aim of the present study was to compare the level of trace elements cadmium (Cd), chromium (Cr), Nickel (Ni), and zinc (Zn) in biological samples (whole blood, urine, and scalp hair) of psoriasis patients of both gender age ranged (25-55 years) at mild, moderate severe, and more severe stage (n = 418) living in the vicinity of cement factory. For comparison purposes, healthy age-matched referent subjects, residents of industrial and non-industrial area, of both gender were also selected (n = 241). The concentrations of trace and toxic elements were measured by atomic absorption spectrophotometer prior to microwave-assisted acid digestion. The validity and accuracy of methodology was checked by using certified reference materials (CRMs) and conventional wet acid digestion method on same CRMs and real samples. The results of this study showed that the mean values of Cd, Cr, Ni, and Pb were significantly higher in scalp hair, blood, and urine samples of mild and severe psoriasis patients as compared to referents (p < 0.001), while the concentration of Zn was lower in the scalp hair and blood, but higher in the urine samples of psoriasis patients. The deficiency of Zn in psoriasis patients may be undoubtedly caused by the toxic element exposures via cement factory.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Cadmium, Chromium, Nickel, and Zinc in Biological Samples of Psoriasis Patients Living in Pakistani Cement Factory Area

Afridi

Kazi

et al. 2010

Biol Trace Elem Res

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“…The unique process of keratinization and melanin formation is enzyme dependent and therefore could be influenced by trace element deficiencies or excesses as trace elements are involved in enzymatic activities and immunologic reactions. Studies have also shown that essential trace elements like iron (Fe), copper (Cu), chromium (Cr), and vanadium (V) underwent redox cycling and had physiological significance [16]. Moreover, iron is necessary for many aspects of free radical metabolism, and its deficiency reduces leukocyte bactericidal when the capacity of iron declines.…”

Section: Discussionmentioning

confidence: 98%

The Effects of FeCl3 and Fe–EDTA on the Development of Psoriasis

Shi

Yang

Chen

2010

Biol Trace Elem Res

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The effects of FeCl₃ and Fe-EDTA on the development of psoriasis were studied in the mouse model of vaginal epithelium and tail epidermis. The mitoses of vaginal epithelial cell in female mice of their estrogenic stage and the formation of granular cell layers in male mouse tail scale were observed. Mice were randomly divided into eight groups and treated with normal saline, methotrexate, and different doses of two iron forms, FeCl₃ and Fe-EDTA, respectively, for 10 days. To explore the influence of FeCl₃ and Fe-EDTA on the excretion of Cu, Fe, Zn, Ca, Mg, Mn, and Se, the concentration of those elements in liver and kidney was analyzed by atomic absorption spectrometry. The different doses of FeCl₃ or Fe-EDTA could obviously inhibit the mitoses of vaginal epithelial cell (p< 0.05) and promote the formation of granular cell layers in mice tail scale (p < 0.05). No statistically significant results were found between the groups of FeCl₃ and Fe-EDTA, and between experimental groups and methotrexate group acted as the positive control (p>0.05). Compared with the negative group, the concentrations of Cu, Fe, Zn, Ca, Mg, Mn, and Se in liver and kidney of experimental groups and positive control group were not significantly changed (p > 0.05). FeCl₃ and Fe-EDTA are as effective as methotrexate on inhibiting hyperplasia of epidermal cells and increasing the formation of granular cell layers, and the concentrations of Cu, Fe, Zn, Ca, Mg, Mn, and Se in liver and kidney of experimental groups and positive control group were not significantly changed compared with the negative group, possibly retarding the development of psoriasis.

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“…Sulfur mineral waters, used for drinking, have antioxidant properties (16). It has been shown that exogenous hydrogen sulphide reduces clonal growth, cell proliferation and cell adhesion of human keratinocytes in psoriasis, but the role of endogenous sulfur in psoriasis is not well claryfi ed, since reduced level has been reported in patients with psoriasis as compared to normal subjects (17). Results obtained in experimental mouse model proved that hydrogen sulphide in sulfur mineral waters signifi cantly reduces edema, inhibits the vascular phase of allergic contact dermatitis and increases plasma concentration of somatostatin.…”

Section: Impact Of Balneotherapy Factors On the Skinmentioning

confidence: 99%

Balneotherapy of Psoriasis

Golušin

Jovanović

Jeremić

et al. 2014

Serbian Journal of Dermatology and Venereology

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Application of different kinds of mineral waters and peloids on the skin exerts mechanical, thermal and chemical effects. Significant reduction of inflammation and increased differentiation of keratinocytes may explain why balneotherapy has positive clinical effects in psoriatic patients. In vitro models have shown that thermal water stimulates interleukin-2 production after cell stimulation by staphylococcal enterotoxin B, and reduces interleukin-4 secretion. After balneotherapy, a significant decrease in Psoriasis Area Severity Index (PASI), associated with a significant reduction of interleukin-8, Staphylococcus aureus colonization and enterotoxin N, have been reported in patients with psoriasis. Mineral water was found to have inhibitory in vitro effects on substance P, TNF-α release and antigen-induced cell degranulation. Immunomodulatory effects of water depend on its content. Sulfur waters have beneficial anti-inflammatory, keratolytic, and antipruriginous effects and also possess antibacterial and antifungal properties. The effectiveness of balneotherapy in the treatment of psoriasis has been reported in many studies conducted all over the world. The majority of studies were conducted at the Dead Sea coast. Investigations showed that balneotherapy factors are important therapeutic factors in the treatment of psoriatic patients. The first and only comparable study of this kind in Serbia, was conducted in Prolom Spa with satisfactory therapeutic results.

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Study on the levels of trace elements in mild and severe psoriasis

Cited by 37 publications

References 22 publications

Evaluation of Cadmium, Chromium, Nickel, and Zinc in Biological Samples of Psoriasis Patients Living in Pakistani Cement Factory Area

Evaluation of Cadmium, Chromium, Nickel, and Zinc in Biological Samples of Psoriasis Patients Living in Pakistani Cement Factory Area

The Effects of FeCl3 and Fe–EDTA on the Development of Psoriasis

Balneotherapy of Psoriasis

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