Study on the Proper D-Xylose Concentration in Sugar Mixture to Reduce Glycemic Index (GI) Value in the Human Clinical Model

Moon, Sung-Hyun; Lee, Kyungsun; Kyung, Myungok; Jung, Sangwon; Park, Yunje; Yang, Changkun

doi:10.9799/ksfan.2012.25.4.787

Cited by 10 publications

(4 citation statements)

References 29 publications

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“…In a previous study, sucrose mixtures containing 5% and 10% D-xylose were associated with significant blood glucoselowering effects in humans [57]. In another study, administration of sucrose solution containing 10% D-xylose exhibited significantly lower under the glucose curve values as well as under the insulin curve values, in an oral glucose tolerance test completed by healthy individuals [22].…”

Section: Discussionmentioning

confidence: 96%

d-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet–induced obese mice

Lim

Shin

et al. 2015

Nutrition Research

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Section: Discussionmentioning

confidence: 96%

d-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet–induced obese mice

Lim

Shin

et al. 2015

Nutrition Research

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“…A recent study showed that the administration of 5% or 10% d -xylose in sucrose mixtures significantly lowered blood glucose levels in humans [45]. Furthermore, administration of 10% d -xylose in a sucrose solution significantly reduced under the glucose curve (AUCg) values and under the insulin curve (AUCi) values obtained from OGTTs performed for healthy individuals [46].…”

Section: Discussionmentioning

confidence: 99%

Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice

Lim

Kim

et al. 2016

Nutrients

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Type 2 diabetes is a major public health concern worldwide. Xylobiose (XB) consists of two molecules of d-xylose and is a major disaccharide in xylooligosaccharides that are used as prebiotics. We hypothesized that XB could regulate diabetes-related metabolic and genetic changes via microRNA expression in db/db mice. For six weeks, C57BL/KsJ-db/db mice received 5% XB as part of the total sucrose content of their diet. XB supplementation improved glucose tolerance with reduced levels of OGTT AUC, fasting blood glucose, HbA1c, insulin, and HOMA-IR. Furthermore, XB supplementation decreased the levels of total triglycerides, total cholesterol, and LDL-C. The expression levels of miR-122a and miR-33a were higher and lower in the XB group, respectively. In the liver, expressions of the lipogenic genes, including, fatty acid synthase (FAS), peroxisome proliferator activated receptor γ (PPARγ), sterol regulatory element-binding protein-1C (SREBP-1C), sterol regulatory element-binding protein-2 (SREBP-2), acetyl-CoA carboxylase (ACC), HMG-CoA reductase (HMGCR), ATP-binding cassette transporter G5/G8 (ABCG5/8), cholesterol 7 alpha-hydroxylase (CYP7A1), and sterol 12-alpha-hydroxylase (CYP8B1), as well as oxidative stress markers, including superoxide dismutase 1 (SOD1), superoxide dismutase 2 (SOD2), glutathione peroxidase (GPX), and catalase, were also regulated by XB supplementation. XB supplementation inhibited the mRNA expressions levels of the pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1, as well as phosphorylation of c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK), p38 mitogen-activated protein kinases (MAPK), and extracellular signal-regulated kinases 1/2 (ERK1/2). These data demonstrate that XB exhibits anti-diabetic, hypolipogenic, and anti-inflammatory effects via regulation of the miR-122a/33a axis in db/db mice.

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“…Some studies examined whether sucrose drinks with 5 % (w/w) D-xylose exerted beneficial effects on enhancing the glycemic response [ 18 , 19 ], but the number of subjects in these studies was too small (n = 10 and n = 13) to define the effect of D-xylose.…”

Section: Discussionmentioning

confidence: 99%

“…The effect of D-xylose occurs via the inhibition of sucrase activity in a non-competitive manner [ 12 ]. Specifically, D-xylose inhibits sucrase activity by combining with the intermediate of sucrase and glucose, immediately after the dissociation of fructose [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design

Jun

Lee

Hwang

et al. 2016

Trials

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BackgroundPrevious studies have reported that xylose selectively inhibited the activity of sucrase. Xylose supplementation may have a beneficial effect on the postprandial glycemic response. However, no studies have investigated patients with IFG or the effectivity of a dose of D-xylose less than 10 % (w/w).MethodsThe present study determined the effect of xylose consumption on postprandial hyperglycemia in normal (n = 25) and hyperglycemic subjects (n = 50). Subjects in this double-blind crossover design study were randomly assigned to consume a sucrose drink (Control, sucrose 50 g + deionized water 100 g) or a sucrose drink additionally containing 5 g (Test 1, sucrose:xylose = 10:1), 3.33 g (Test 2, sucrose:xylose = 15:1), or 2.5 g (Test 3, sucrose:xylose = 20:1) of D-xylose separated by a one-week interval.ResultsNormal subjects in all test groups exhibited a significant decrease in serum glucose levels 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. Significantly lower serum levels of insulin were observed at 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. The test 1 group also exhibited a significantly lower insulin area under the curve than the control group. Hyperglycemic subjects (n = 50) in all test groups exhibited a significant decrease in serum glucose levels at 30 min compared to the control group. However, the test 1 group exhibited a significant increase in serum glucose levels at 120 min compared to the control group. Glucose-related markers did not significantly differ in each group.ConclusionXylose supplementation may exert a beneficial effect on postprandial glycemic responses in subjects with normal glucose levels and prediabetes.Trial registrationClinicalTrials.gov identifier: NCT02654301. Registered 12 January 2016.

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Study on the Proper D-Xylose Concentration in Sugar Mixture to Reduce Glycemic Index (GI) Value in the Human Clinical Model

Cited by 10 publications

References 29 publications

d-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet–induced obese mice

d-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet–induced obese mice

Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice

Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design

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