Study on the surface-modification of nano-hydroxyapatite with lignin and the corresponding nanocomposite with poly (lactide-co-glycolide)

Ding, Hongyan; Liuyun, Jiang; Tang, Chunyan; Tang, Shuo; Ma, Bingli; Zhang, Na; Yue, Wen; Zhang, Yan; Sheng, Liping; Su, Shengpei; Hu, Xiang

doi:10.1007/s11705-020-1970-5

Cited by 13 publications

(4 citation statements)

References 32 publications

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“…Such modifications include the addition of dodecyl alcohol or silica and polymerization of lactide on the surface of particles to improve the mixing of HAp with oleophilic media (e.g., polymer or polymer solution in an organic solvent). − Another approach to improve the HAp mixing with polymers includes applying an organic polymer, that is, lignin, in a co-precipitation process . The mentioned approaches aimed at increasing the mechanical properties of composite materialspolymer/ceramiccontaining HAp particles.…”

Section: Introductionmentioning

confidence: 99%

“…16−18 Another approach to improve the HAp mixing with polymers includes applying an organic polymer, that is, lignin, in a coprecipitation process. 19 The mentioned approaches aimed at increasing the mechanical properties of composite materials polymer/ceramiccontaining HAp particles. For non-medical applications of HAp, the surface properties of the particles and their morphology can be controlled by the addition of surfactants to the reaction systems.…”

Section: Introductionmentioning

confidence: 99%

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Scaled-Up 3D-Printed Reactor for Precipitation of Lecithin-Modified Hydroxyapatite Nanoparticles

Wojasiński

Latocha

Liszewska

et al. 2021

Ind. Eng. Chem. Res.

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We propose a scaled-up reactor for the synthesis of hydroxyapatite nanoparticles (nHAp) applicable for lecithin-modified precipitation. A novel 3D-printed BOX reactor allowed, confirmed by computational fluid dynamics analyses, maintaining or improving the hydrodynamic conditions corresponding to the conditions within single-channel millireactors described in our previous work. As confirmed by X-ray diffraction analysis, we obtained hydroxyapatites. Fourier-transform infrared spectroscopy showed the same characteristic functional groups in powders from single-channel millireactors and BOX reactors. Scanning transmission electron microscopy showed that regardless of lecithin modification, the hydroxyapatite powders from the BOX reactor have particles of the same size as those from the single-channel millireactors; the particle size does not exceed 30 nm. Moreover, nanoparticle tracking analysis and dynamic light scattering show that regardless of the selected reactor and the presence of surface modification, particles tend to agglomerate, which we confirmed in zeta potential measurements. The nHAp’ chemical and physical properties and the lecithin-modified nHAp obtained in the BOX reactor do not depend significantly on the reactants’ flow rate, so it is possible to obtain particles with a precipitate suspension productivity of up to 150 g/h. The presented method of hydroxyapatite wet precipitation scale-up is a step toward stable and efficient production of a restorative material for medical and dental applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Scaled-Up 3D-Printed Reactor for Precipitation of Lecithin-Modified Hydroxyapatite Nanoparticles

Wojasiński

Latocha

Liszewska

et al. 2021

Ind. Eng. Chem. Res.

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“…The methods of HAp and nHAp modifications discussed in the literature include grafting polymers onto the surface of particles, for example, PCL and PLA, 11,15 and chemical surface modification. [16][17][18][19][20][21][22] The methods presented in the literature involve at least two stages that require complex procedures.…”

Section: Introductionmentioning

confidence: 99%

Mechanically suitable and osteoinductive 3D‐printed composite scaffolds with hydroxyapatite nanoparticles having diverse morphologies for bone tissue engineering

Wojasiński,

Podgórski,

Kowalczyk

et al. 2024

J Biomed Mater Res

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The challenge of integrating hydroxyapatite nanoparticles (nHAp) with polymers is hindered by the conflict between the hydrophilic and hygroscopic properties of nHAp and the hydrophobic properties of polymers. This conflict particularly affects the materials when calcium phosphates, including nHAp, are used as a filler in composites in thermal processing applications such as 3D printing with fused filament fabrication (FFF). To overcome this, we propose a one‐step surface modification of nHAp with calcium stearate monolayer. Moreover, to build the scaffold with suitable mechanical strength, we tested the addition of nHAp with diverse morphology—spherical, plate‐ and rod‐like nanoparticles. Our analysis showed that the composite of polycaprolactone (PCL) reinforced with nHAp with rod and plate morphologies modified with calcium stearate monolayer exhibited a significant increase in compressive strength. However, composites with spherical nHAp added to PCL showed a significant reduction in compressive modulus and compressive strength, but both parameters were within the applicability range of hard tissue scaffolds. None of the tested composite scaffolds showed cytotoxicity in L929 murine fibroblasts or MG‐63 human osteoblast‐like cells, supporting the proliferation of the latter. Additionally, PCL/nHAp scaffolds reinforced with spherical nHAp caused osteoactivation of bone marrow human mesenchymal stem cells, as indicated by alkaline phosphatase activity and COL1, RUNX2, and BGLAP expression. These results suggest that the calcium stearate monolayer on the surface of the nHAp particles allows the production of polymer/nHAp composites suitable for hard tissue engineering and personalized implant production in 3D printing using the FFF technique.

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“…The controllable fractionation of heterogeneous lignin into several lignin fractions characterized by good homogeneity and stable properties is the key to realizing the high value-added applications of lignin [9][10][11][12][13] . Lignin fractionation methods primarily include the processes of membrane ultrafiltration, gradient acid precipitation, and sequential solvent extraction.…”

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confidence: 99%

An integral method for determining the molecular composition of lignin and its application

Zhang

2022

Sci Rep

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Lignin is a natural and renewable aromatic polymer, but only about 2% of lignin is utilized with high added value. Polydispersity and heterogeneity are the key reasons for the difficulty in separation, fractionation, characterization, purification and utilization of lignin. However, the molecular weight of lignin is still described from the overall perspective of number-/weight-average molecular weight (Mn and Mw), which if far from enough to understand the heterogeneous and dispersed lignin. To provide a tool for understanding the molecular weight of lignin from a molecular perspective, an integral method for quantifying the molecular characteristics of lignin molecules at arbitrary molecular intervals on the molecular weight distribution curve of lignin was established. The molecular contents of wheat straw lignin as well as its soluble and insoluble fractions at different intervals were calculated. The ease of fractionation of small molecules with weights lower than 8000 g/mol into soluble fractions, and that of large molecules with weights higher than 10,000 g/mol into insoluble fractions were quantitatively analyzed. The established integral method will significantly help in the understanding the properties of lignin at the molecular-level, as well as the fractionation and utilization of lignin.

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Study on the surface-modification of nano-hydroxyapatite with lignin and the corresponding nanocomposite with poly (lactide-co-glycolide)

Cited by 13 publications

References 32 publications

Scaled-Up 3D-Printed Reactor for Precipitation of Lecithin-Modified Hydroxyapatite Nanoparticles

Scaled-Up 3D-Printed Reactor for Precipitation of Lecithin-Modified Hydroxyapatite Nanoparticles

Mechanically suitable and osteoinductive 3D‐printed composite scaffolds with hydroxyapatite nanoparticles having diverse morphologies for bone tissue engineering

An integral method for determining the molecular composition of lignin and its application

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