Study on the Use of Resveratrol as an Adjuvant in Cancer Therapy

Abstract

Chemotherapy, the most widely used therapy in oncology, leads to the accumulation of reactive oxygen species, which often generates adverse effects in patients. To reduce the oxidative stress due to either the action of cytostatics or pathological tumour mechanisms, we analyzed the effectiveness of antioxidants. The use of antioxidants as adjuvant therapy can improve the therapeutic effects by potentiating the antitumour action of cytostatics and reducing their toxicity to healthy tissues.The aim of this study was to evaluate the efficacy of resveratrol administered 3 days after Epirubicin in Wistar rats inoculated with Walker tumour 256. In our experiment we evaluated three indices of oxidative stress and found that the lowest values were recorded at the group receiving resveratrol, thus emphasizing the beneficial antioxidant action of resveratrol.