Study on vitamin D receptor gene polymorphisms in patients with urinary tract infections conducted in Northwestern Mexico

Becerra-Loaiza, Denisse Stephania; Sánchez-Zazueta, Jorge Guillermo; Ochoa‐Ramírez, Luis Antonio; Velarde-Rodríguez, Ismael; Rodríguez-Millán, José; Velarde‐Félix, Jesús Salvador

doi:10.48193/revistamexicanadeurologa.v78i6.100

Cited by 1 publication

(3 citation statements)

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“…Limited research has conducted on the association between VDR polymorphisms in adult women and rUTI. Earlier studies have supported an association among polymorphisms in the VDR gene, UTI recurrence [ 7 ] and children [ 9 ]. Our study participants were adult women, and the findings may not be generalizable to children or men.…”

Section: Discussionmentioning

confidence: 91%

“…Vitamin D is involved in the first line of defence against bacterial infections within the urothelium via its nuclear receptor and it has antibacterial properties [ 7 – 9 ]. Vitamin D promotes monocyte differentiation and inhibits lymphocyte proliferation and secretion of cytokines such as interleukin-2, interferon-γ and interleukin-12 [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Research indicates that rs1544410 VDR has an impact on how effectively vitamin D can boost the production of antimicrobial peptides. This can lead to a reduced ability to eliminate bacterial uropathogens, potentially contributing to rUTIs [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

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VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study

Sarker,

Pereira,

Khullar

et al. 2024

Int Urogynecol J

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Introduction and hypothesis Urinary tract infection (UTI) is one of the most common human infections. Evidence suggests that there might be a genetic predisposition to UTI. Previous small candidate gene studies have suggested that common variants in genes involved in the immune response to UTI could increase susceptibility to the development of recurrent UTI (rUTI). The objective was to conduct a gene association study to replicate previous gene association studies identifying single nucleotide polymorphisms (SNPs) putatively associated with rUTI in adult women. Methods Women with a history of rUTI and healthy controls were recruited (n = 1,008) from gynaecology outpatient clinics. Participants completed a signed consent form and questionnaire for phenotyping. DNA was extracted from blood or saliva samples for each participant. Putative associated SNPs were identified from a comprehensive systematic review of prior gene association studies. Primers for each selected SNP were designed, and genotyping was conducted using a competitive polymerase chain reaction (PCR) method. The Chi-squared test was used to assess the association between each variant and rUTI. Genotyping quality was assessed by checking for deviation from Hardy–Weinberg equilibrium. Results We found no association between SNPs tested in the VDR (p = 0.16, p = 0.09, p = 0.36), CXCR1 (p = 0.09), CXCR2 (p = 0.39), PSCA (p = 0.74) genes, and rUTI in adult women. Conclusions To our knowledge, this is the largest study to date, finding no significant associations. Previously reported positive associations may have been due to type 1 error, or genotyping errors. Future studies should adjust for confounders and employ adequate sample sizes. A greater understanding of the genetic components associated with rUTI may influence future treatment guidelines and screening for susceptible patients.

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Section: Discussionmentioning

confidence: 91%