Study protocol epidemiology of inflammatory bowel disease in childhood and adolescence: a systematic review

Abstract

IntroductionThe incidence and prevalence of chronic inflammatory bowel diseases in childhood and adolescence is increasing and varies internationally. The systematic literature review aims to describe international epidemiological trends of chronic inflammatory bowel diseases in the child and adolescence age. A period from 1970 to 2019 will be taken into account when searching for suitable studies as well as geographical differences in the development of incidences will be presented.Methods and analysisThe literature databases PubMed and Embase will be searched for the period from 01 January 1970 to 31 December 2019 using linked keywords. A manual search in bibliographies of already published and relevant systematic reviews will complete the systematic literature search. The included studies will be combined in a qualitative and quantitative synthesis and statistically evaluated.Ethics and disseminationEthical approval is not required for this study as it is a systematicreview. The results will be submitted to peer-reviewed journals and presented in national andinternational meetings. This research received no specific grant from any funding agency inthe public, commercial or not-for-profit sectors. This systematic review protocol was registeredwith the International Prospective Register of Systematic Reviews (PROSPERO-NR:CRD42020168644).

A systematic review and meta-regression on international trends in the incidence of ulcerative colitis in children and adolescents associated with socioeconomic and geographic factors

“…The systematic review search has been registered in Prospero (PROSPERO-NR: CRD42020168644). To enhance methodological transparency, the study protocol "Epidemiology of inflammatory bowel disease in childhood and adolescence: a systematic review" was published previously [20].Consequently, we followed the guidelines outlined in the PRISMA statement for our systematic review [21]. The systematic literature search was conducted using the PubMed and EMBASE databases via OVID.…”

“…Additionally, a manual search of the bibliographies of previously published and relevant systematic reviews was conducted. For more detailed information on our methodology, inclusion and exclusion criteria, and systematic review screening, we refer to the published study protocol [20]. For the present study, we updated the previous systematic literature search in 2021/2022 by applying the previous search string and expanding the study period to include studies published through 2021 and covering the observation period from 1970 to 2019.…”

“…IBD spectrum diseases are often diagnosed in childhood and adolescence. Approximately 20 percent of IBD cases are diagnosed before the age of 20 years, with an adverse shift in age of diagnosis to the early childhood years [3][4][5][6]. UC is a worldwide chronic illness, with the most noteworthy rates of occurrence historically recorded in North America and Northern Europe.…”

“…Particularly, the impact of the Western lifestyle on immunmodulated diseases, such as UC and CD, is a subject of discussion. These diseases exhibit correlations not only with socioeconomic factors but also with geographic and environmental variables [6,[14][15][16]. The clinical course of children with UC differs from adults, so the direct health care costs may be higher in children with UC compared with adults.…”

Content of Telephone Consultations of Patients With Inflammatory Bowel Disease

“…Patients with IBD need to be treated for life, changing medications according to their symptoms (Nakase et al, 2021). A majority of IBD patients develop IBD in their late teens and twenties (Ng et al, 2018; Weidner, Kern, Manuwald, Kugler, & Rothe, 2020). Patients need to continue disease management throughout various stages of their life, such as at school, employment, marriage, and in pregnancy and childbirth.…”