Study the association between IL-17 level and autoimmune antibodies in hypo and hyper thyroidisms patients

Abstract

The current study included measuring the level of IL-17A and IL-17F and some autoimmune antibodies related to the thyroid gland in case of hypo and hyperthyroid in Iraqi patients to evaluate the correlation between all the measured parameters in this study.The study has been carried out in AL-Kindey Endocrine Gland and Diabetic Center in Baghdad during the period between February 2018 and May 2018, included: 88 patients were divided into three groups, The first group composed of 30 patients of Hypothyroidism that included (26) of them were females, (4) of them males. The second group composed of 30 of patients of Hyperthyroidism that included (20) of them were females, (10) of them were males . and second groups were conducted with hypo and hyperthyroidism respectively.While the third group composed of 28 of healthy individuals (Control) that composed of (25) of them were females, (3) of them were males was represented as control .The results revealed a significant (P < 0.05) correlation between TSH concentration and age in patients groups. When the age is more than 40 years, the concentration of TSH was noticed to be higher than that in patients aged less than 40 years. The results show that the level of antibodies was significantly increased (P<0.01) in hypo and hyperthyroid patients in comparison with the control group. At the same time the level of Anti-TG antibodies was higher significantly in the hypothyroid patients than its level in hyperthyroid patients group. No significant differences have been found between hypo and hyperthyroid patients in the level of Anti-TPO and Anti TSH-R antibodies. But its noticed that the higher level of Anti-TPO Ab. was found in the hypothyroid group where as higher level of Anti TSH-R Ab. was found in the hyperthyroid group and simultaneously both types were significantly higher than their levels in the control group As well as the results demonstrated a highly significant increase (P< 0.01) in the levels of IL-17 Types (A and F) in hypo and hyperthyroid patients with bias toward the comparison with the control group. The statistical study showed a significant negative correlation between the level of TSH and Anti-TG levels (r= -0.33). While a significant positive correlation between the level of Anti-TG and level of IL-17F (r= 0.39) in hypothyroid patients. Also in hypothyroid patients, there is a significant positive correlation between the level of Anti-TPO and IL-17A (r= 0.33). In conclusion: The positive correlation between IL-17F and Anti-TG and between IL-17A and Anti- TPO in hypothyroid patients refer to increase in the concentration of IL-17 may lead to increase the thyroid autoantibodies, which affect thyroid tissue potency, decreasing thyroid hormone production, according to feedback inhibition loop.

Serological and Molecular Evaluation of Mrp14 in Thyroiditis and Its Role in Pro-Inflammatory Chemokines Activation

“…Therefore, the level of anti-TG in hyperthyroid patients is much greater than in hypothyroid patients (364.2 ± 46.96 vs 257.5 ± 28.91 IU/ml). The results agreed with the study of (20), which demonstrated the level of anti-TG antibodies in hyperthyroidism patients was highly significant (P < 0.01) than in a control group, and also in the hypothyroidism patients group. Thyroid autoimmunity may play the role in the clinical symptoms of HT, as seen by elevated TgAb level in Hashimoto's Thyroiditis patients (10).…”

Association of CTLA-4 Single Nucleotide Polymorphisms with Autoimmune Hypothyroidism in Iraqi Patients

“…For autoantibodies status, it was found that about half of the patients (49.3%, n=37) were positive for both anti-TG and anti-TPO while the remaining patients were positive for either of them. In total, and as shown in table (1), 92 % (n=69) of patients were positive for anti-TPO with a median of 282.9 (range: 41.6-1154.0 IU/ml) and 57.3 % (n=43) of them were positive for anti-TG with a median of 471.7 (range: 122.3 -2998.9 IU/ml). Individuals in the control group had either undetectable concentrations of these autoantibodies or their concentrations were below the cut-off values of 40 IU/ml and 120 IU/ml for anti-TPO and anti-TG respectively.…”

“…Triiodothyronine (T3) and Thyroxine (T4) are hormones secreted exclusively from the thyroid gland and required by all metabolically active cells; therefore, deficiency or impaired activity of these hormones can result in hypothyroidism which is a common disorder of the endocrine system with a wide range of effects on the body [1]. Hypothyroidism can be presented as Hashimoto's thyroiditis (HT) which is a form of autoimmune thyroid disease (AITD) resulting from T cell-mediated organ-specific immune response against the thyroid gland resulting from immune system deregulation [2].…”

Changes in biochemical, immunological and inflammatory parameters in hyper and hypothyroidism: A systematic review

“…Anti-thyroid globulin has a positive association with IL-17f while anti-thyroid peroxidase has an association with IL-17a in a hypothyroid patient. Hence, a higher level of IL-17 leads to an increase in thyroid autoantibodies which might damage the thyroid gland (26). In India, vitiligo disease is linked with thyroid disorders which makes it necessary to screen vitiligo patients for autoimmune thyroid diseases (AITD) on regular basis (1).…”