Study the protective effect of Matricaria chamomilla flower extract against the toxicity of Entamoeba histolytica induces liver and renal dysfunctions in adult albino male rats

Abstract

The present study was designed to show the potential role of Matricaria chamomilla flower extract against toxicity of Entamoeba histolytica . The study used 20 adult albino male rats that divide randomly to four groups (each group consist 5 rats); control group received ad libidium, group of rats administrated with 1X10 3 cyct/ml suspension for seven days, group of rats administrated with 1X10 3 cyct/ml suspension and treated with 50mg/kg extract for month, group of rats administrated with 1X10 3 cyct/ml suspension and treated with 100mg/kg extract for month. The results show high significant increased (P < 0.05) in levels of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), urea, creatinine and uric acid in rats administrated with 1X10 3 cyct/ml suspension. Oxidative stress factor in this group show significant increased (P < 0.05) in levels of MDA (malonedialdehyied) and significant decreased (P < 0.05) in levels of glutathione (GSH) and catalase compared with control group. While, after used M. chamomilla flower extract with Entamoeba histolytica , the results showed non significant changes (P < 0.05) in liver and kidneys function parameters. Also, MDA, GSH and catalase showed non significant changes (P < 0.05) compared with control group. It was concluded that flower extract has been potential role against toxicity of Entamoeba histolytica in adult male albino rats. Science, 2018, Vol. 59, No.2B, pp: 832-838 Keywords IntroductionMatricaria chamomilla (MC) or German chamomile, also spelled chamomile, is one of the most used in medicine field. The plant has been included in the pharmacopoeia of 26 countries [1]. Its found in different countries such as Asia, Australia, North Africa, North and South America [2]. Two species of Matricaria are used in herbalism, Chamaemelum nobile and Matricaria chamomilla [3]. Matricaria chamomilla consist of different types of potential compounds including; terpenoids α-bisabolol, , polysaccharides, essential oils, mineral elements, , fatty acids, flavonoids, and other phenolic [1,4]. Matricaria chamomilla has been different actions in medical line include antibacterial, anti-inflammatory, antifungal, anti-ulcer, antispasmodic, antiviral, and sedative effects [5]. Matricaria chamomilla is used internally mainly as sluggish digestion, for diarrhea and nausea; the urinary tract and for painful menstruation. Externally, may be applied to wounds slow to heal, skin eruptions, infections, such as shingles and boils, throat, hemorrhoids, and eyes [2,6].Infections by Entamoeba histolytica lead to different clinical manifestations and disease, including dysentery, diarrhea, and hepatic liver abscess. Approximately 50 million person in world are affected by E. histolytica and approximately 100,000 person die every year in world [7]. Infection by this parasite is occurs when the host ingests cyst phases in contaminated food or water. After that, trophozoites are released in the small intestine, may colonize the large intestine and ...

Chamomile (Matricaria chamomilla L.): A Review of Ethnomedicinal Use, Phytochemistry and Pharmacological Uses

“…Moreover, the extract showed a protective effect against formaldehyde in male rats' reproductive system [49] and against torsion/detorsion-induced damages on adult rat testis tissue [188] and ovary tissue [189]. On the other hand, M. chamomilla extracts showed a therapeutic effect against thyroid damage [190] and kidney dysfunction [191] associated with polycystic ovary syndrome in female rats.…”