Study the Role of Some Types of T Lymphocytes in Toxoplasmosis

Abstract

Toxoplasma gondii has become increasingly recognized as an important pathogen of humans and domestic animals. It is one of the most common causes of latent infections in humans over the world. Venous blood was collected from the patients and controls, A total of sixty women with a history of abortion and twenty-four healthy-looking controls were included in this study. Forty-four women were found to have Toxoplasma infection, fourteen women with anti-Toxoplasma IgM antibody (acute infection), eighteen with anti-Toxoplasma IgG antibody (past or chronic infection), and twelve with both IgG and IgM antibodies (recurrent infection). CD3, CD4, CD8, and CD71 were used and the results showed a significant elevation of these markers in women with toxoplasmosis when compared to the healthy controls. Toxoplasmosis cause both acute and chronic infections leading to stimulate T lymphocytes that provide protection against multiple infections and prevent occurrence of complications.

The relationship between toxoplasmosis and different types of human tumors

“…Human toxoplasmosis has frequently been mild or self-limiting in immunocompetent patients but serious in immunodeficient ones [4]. Tissue cysts, which are controlled by the cellular immune system, represent its sustainability inside the host [5]. This parasite can persist in active form for a longer period within immunologically advantaged sites such as the brain and the eye [6].…”

Histopathological, Immunohistochemical and Biochemical Studies of Murine Hepatosplenic Tissues Affected by Chronic Toxoplasmosis

“…On the other hand, CD3 subsets have been activated, and their numbers increased in the peripheral blood and spleen of immunized and chronically infected mice [ 32 ]. In the sera of women infected with T. gondii , CD3 T cells were significantly upregulated compared to healthy controls, indicating that the lymphocytes are proliferating rapidly because of exposure to the Toxoplasma antigens [ 33 ]. The threshold of activation and differentiation of CD138 plasma cells is lowered during Toxoplasma infection [ 34 ].…”