“…In-cell NMR serves as a promising approach to provide structural and dynamics data on protein-protein interaction and protein-ligand interaction systems in cellular environments [ 45 , 49 , 151 ]. Generally, in-cell NMR can be carried out in bacteria, yeast, sf9, frog oocytes, zebrafish embryo, and human cells without further sample purification, and it has become a remarkable tool for drug discovery [ 45 , 152 , 153 , 154 , 155 , 156 , 157 , 158 ]. Multiple cases related to the applications of in-cell NMR in drug discovery have been reported.…”