Studying the Link Between Idiopathic Pulmonary Fibrosis and Gi Reflux Disease: A Nationwide Perspective

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial pneumonia that has been shown to have an association with gastroesophageal reflux disease (GERD) possibly due to chronic micro-aspiration leading to remodeling of the lung parenchyma. While a causal relationship between these two pathologies has not been clearly demonstrated to date, prior studies suggest they are closely related with GERD being more common in IPF than the general population. This study sought to further investigate the potential link between GERD and IPF as well as characterize sources of inpatient mortality in patients with concurrent disease.METHODS: Data from the National Inpatient Sample (NIS) database for 2015-2016 was used to assess the prevalence of IPF and the major causes of inpatient mortality in patients with both GERD and IPF. All hospitalizations with GERD (ICD-10-CM K21.0 and K21.9) were analyzed. Univariate and multivariate logistic regression analyses were performed and was adjusted for age, sex, race. SPSS was used for data analysis.