Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease

Yin, Han; Fang, Jun; Лонг, Линг; Nakamura, Hideaki; Maeda, Hiroshi

doi:10.1016/j.jconrel.2014.05.018

Cited by 94 publications

(86 citation statements)

References 34 publications

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“…Fang et al . also showed that carbon monoxide‐releasing micelles enhanced drug delivery . In addition, tumor necrosis factor‐ α and tumor growth factor‐ β receptor inhibitor (LY364947) had similar EPR‐inducing effects.…”

Section: Introductionmentioning

confidence: 88%

A Retrospective 30 Years After Discovery of the Enhanced Permeability and Retention Effect of Solid Tumors: Next‐Generation Chemotherapeutics and Photodynamic Therapy—Problems, Solutions, and Prospects

2016

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Solid tumor has unique vascular architecture, excessive production of vascular mediators, and extravasation of macromolecules from blood vessels into the tumor tissue interstitium. These features comprise the phenomenon named the EPR effect of solid tumors, described in 1986. Our investigations on the EPR revealed that many mediators, such as bradykinin, NO, and prostaglandins, are involved in the EPR effect, which is now believed to be the most important element for cancer-selective drug delivery. However, tumors in vivo manifest great diversity, and some demonstrate a poor EPR effect, for example, because of impaired vascular flow involving thrombosis, with poor drug delivery and therapeutic failure. Another important element of this effect is that it operates in metastatic cancers. Because few drugs are currently effective against metastases, the EPR effect offers a great advantage in nanomedicine therapy. The EPR effect can also be augmented two to three times via nitroglycerin, ACE inhibitors, and angiotensin II-induced hypertension. The delivery of nanomedicines to tumors can thereby be enhanced. In traditional PDT, most PSs had low MW and little tumor-selective accumulation. Our hydroxypropylmetacrylamide-polymer-conjugated-PS, zinc protoporphyrin (apparent MW >50 kDa) showed tumor-selective accumulation, as revealed by fluorescent imaging of autochthonous cancers. After one i.v. injection of polymeric PS followed by two or three xenon light irradiation/treatments, most tumors regressed. Thus, nanoprobes with the EPR effect seem to have remarkable effects. Enhancing the EPR effect by using vascular modulators will aid innovations in PDT for greater tumor-targeted drug delivery.

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Section: Introductionmentioning

confidence: 88%

A Retrospective 30 Years After Discovery of the Enhanced Permeability and Retention Effect of Solid Tumors: Next‐Generation Chemotherapeutics and Photodynamic Therapy—Problems, Solutions, and Prospects

2016

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“…6b). 53 The release rate of CO of the composite was found to be slower than that of free CORM-2. When mice were treated with the composite, up-regulation of inflammatory cytokines was significantly suppressed compared to CORM-2 due to suppression of the cytotoxic effect.…”

Section: Synthetic Polymer Materialsmentioning

confidence: 87%

“…78 Micelle compounds consist of both hydrophilic and hydrophobic components, which improve the solubility and stability of metal complexes in living cells. 18,53,54 In an effort to construct micelle-based CORMs, CORM-3 was covalently anchored between a hydrophilic poly(ethylene glycol) (PEG) block and a hydrophobic poly(n-butylacrylamide) block (Fig. 6a).…”

Section: Synthetic Polymer Materialsmentioning

confidence: 99%

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Design of biomaterials for intracellular delivery of carbon monoxide

2015

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Carbon monoxide (CO) is recognized as one of the most important gas signaling molecules involved in governing various therapeutic responses. Intracellular generation of CO is spatiotemporally controlled by catalytic reactions of heme oxygenases (HOs). Thus, the ability to control intracellular CO delivery with modulation of the CO-release rate in specific amounts and locations is expected to improve our fundamental understanding of the functions of CO and the development of clinical applications. For this purpose, CO-releasing molecules (CORMs) have been developed and investigated in vitro and in vivo. Most CORMs are based on transition metal carbonyl complexes. Recently, various biomaterials consisting of metal carbonyls with biomacromolecular scaffolds have been reported to improve the properties of bare metal carbonyls. In this mini-review, current progress in CO delivery, recent strategies for the development of CORMs, and future directions in this field are discussed.

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“…Currently we do not have direct evidences whether it enters the circulation acting systemically or reaches colon acting locally, after oral administration. However, our previous study using polymeric micelles suggested that polymeric micelles may travel through the stomach and enter the intestine [48].…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG–AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases

Fang

Yin

Лонг

et al. 2016

Journal of Controlled Release

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Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease

Cited by 94 publications

References 34 publications

A Retrospective 30 Years After Discovery of the Enhanced Permeability and Retention Effect of Solid Tumors: Next‐Generation Chemotherapeutics and Photodynamic Therapy—Problems, Solutions, and Prospects

A Retrospective 30 Years After Discovery of the Enhanced Permeability and Retention Effect of Solid Tumors: Next‐Generation Chemotherapeutics and Photodynamic Therapy—Problems, Solutions, and Prospects

Design of biomaterials for intracellular delivery of carbon monoxide

Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG–AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases

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