Su Jok therapy is used as an energy-based complementary and alternative method in cancer patients. The study was conducted to determine the effects of Su Jok therapy on pain, fatigue, insomnia, nausea, and vomiting experienced by patients with gastrointestinal cancer. This randomized controlled trial was conducted with 48 patients. Data were collected by the researcher by using an introductory information form, the short form McGill pain questionnaire, the cancer fatigue scale, the insomnia severity index, the Rhodes index of nausea, vomiting, and retching, and the visual analog scale. It was found that, after the application of Su Jok seed treatment, there was a significant decrease in the mean scores of the intervention group on the McGill pain scale, the cancer fatigue scale, the insomnia severity index, and the Rhodes index of nausea, vomiting, Su Jok therapy was effective in reducing the pain, fatigue, insomnia, nausea, and vomiting scores of patients with gastrointestinal cancer.