Su1127 In Vitro Topical Protection of Human Esophageal Mucosal Integrity by Natural Products From the Northeast Region of Brazil

Topical protection of mice laryngeal mucosa using the natural product cashew gum

“…The topical application of 10% cashew gum prevented a reduction in TER and an increase in transepithelial permeability in the laryngeal mucosa exposed to TDC in a weakly acidic solution. De Lima et al described the in vitro protective effect of cashew gum applied topically in esophageal mucosa exposed to acidic solution containing pepsin and TDC . These researchers further explained that this effect is likely due to its muco‐adhesiveness properties, which are provided by complex polysaccharides.…”

“…De Lima et al described the in vitro protective effect of cashew gum applied topically in esophageal mucosa exposed to acidic solution containing pepsin and TDC. 15 These researchers further explained that this effect is likely due to its muco-adhesiveness properties, which are provided by complex polysaccharides. Cashew gum is a nontoxic, stable, easily available, biodegradable, and inexpensive substance.…”

“…Cashew gum, a natural polymer obtained from the resin of a Brazilian northeastern tree ( Anacardium occidentale L.), is a biomacromolecule with adhesive properties and anti‐inflammatory and gastro‐protective characteristics in animal models . Experiments in our lab showed that precoating human esophageal biopsies with cashew gum solution confers protection against acidic solution containing pepsin and bile acids …”

“…13,14 Experiments in our lab showed that precoating human esophageal biopsies with cashew gum solution confers protection against acidic solution containing pepsin and bile acids. 15 To the best of our knowledge, there are no studies regarding the effect of any topical protectant solution against the damage caused by refluxate components to the laryngeal mucosa. This study aimed to evaluate the effect of in vitro exposure of mice laryngeal mucosa to solutions that simulated human gastric juice and to assess the topical protective effect of cashew gum on mice laryngeal mucosal integrity in vitro.…”