Su1620 Mast Cells in the Gastric Antrum, Its Relation With Functional Dyspepsia. a Multicenter Study in a South-American Country

Pignataro, Susana B.; Barcia, Teresa; Campitelli, Esteban H.; Adriana, M.; Ibarra, Daniela; Paszkiewich, Alicia; Pere, Flavio O.; Regnasco, Santiago J.; Rubio, Horacio W.; Saa, E; Casco, Claudia; Jaroslavsky, Maria J.; Racca, M; Ronchetti, Ruben

doi:10.1016/s0016-5085(12)61764-8

Cited by 2 publications

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“…Gastric mast cells were increased in individuals with FD (SMD = 0.94, 95%CI 0.26‐1.62, P = .007) compared to controls when data were pooled from 5 studies (Figure A) . The random effect model was used given presence of heterogeneity among studies ( I 2 = 88%, P < .001), but no publication bias (Egger's test P = .489) was detected.…”

Section: Resultsmentioning

confidence: 99%

“…Gastric mast cells were increased in individuals with FD (SMD = 0.94, 95%CI 0.26-1.62, P = .007) compared to controls when data were pooled from 5 studies ( Figure 2A). 7,[11][12][13][14] The random effect model was used given presence of heterogeneity among studies (I 2 = 88%, P < .001), but no publication bias (Egger's test P = .489) was detected. In a subgroup analysis of 3 studies evaluating individuals with documented absence of H. pylori infection (139 with FD, 63 controls), mast cell counts remained elevated in FD (SMD = 1.23, 95%CI 0.01-2.45, P = .048) compared to the control.…”

Section: Immune Markers In Gastric Mucosamentioning

confidence: 99%

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Micro‐inflammation in functional dyspepsia: A systematic review and meta‐analysis

Chen

Kim

et al. 2018

Neurogastroenterology Motil

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Functional dyspepsia (FD) is a gastrointestinal disorder of unknown etiology. Although micro-inflammation appears to be important in the pathogenesis, studies evaluating immune activation in FD have been inconsistent. A systematic review of literature and meta-analysis was performed to compare immunologic cell counts and cytokine levels in the mucosa and peripheral blood of individuals with FD and healthy controls. PubMed, Embase, and the Cochrane library were searched. Data on immunologic cell counts and cytokines levels among individuals with FD and control groups were extracted and compared by calculating standard mean differences (SMD). Thirty-seven studies met the inclusion criteria. Mast cell (SMD = 0.94, 95%CI 0.26-1.62, P = .007) and eosinophil counts (SMD = 0.36, 95%CI 0.06-0.68, P = .03) in the stomach were increased, among individuals with FD compared to controls. Similarly, mast cell (SMD = 0.66, 95%CI 0.20-1.13, P = 0.005) and eosinophil (SMD = 0.95, 95%CI 0.66-1.24; P < .001) counts in the duodenum were also increased in those with FD compared to controls. In a subgroup analysis, elevated eosinophil counts in the duodenum were observed in both post-prandial distress syndrome (SMD = 0.97, 95%CI 0.46-1.47, P = .0002) and epigastric pain syndrome subtypes (SMD = 1.16, 95%CI 0.48-1.83, P = .0008). No differences in mucosal intraepithelial lymphocyte, enterochromaffin cell, and neutrophil counts, as well as, peripheral interlukin-6 (IL-6) and IL-10 levels were observed among individuals with FD and controls. Micro-inflammation in the form of local immune cell infiltration, particularly eosinophils and mast cells, characterizes the pathogenesis of FD.

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Section: Resultsmentioning

confidence: 99%