Su2110 Brain Processing of Visual Motion Induced Nausea in Healthy Humans

Ng, Kee Seong; Chua, Ying Xian; Ban, Vin Fei; Gresty, Michael A.; Gampietro, Vincent; Coen, Steven J.; Sanger, Gareth J.; Fitch, Katherine; Heng, Roy J.; Ruffle, James K.; Williams, Steven; Barker, Gareth; Andrews, Paul; Aziz, Qasim

doi:10.1016/s0016-5085(13)62071-5

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“…Motion video. Nausea was induced by watching a video of a rotating and tilted landscape through a pair of goggles (to limit the field of view) (32). During the video, volunteers were asked to rate their nausea and anxiety levels on a VAS scale (no-mild-moderatesevere/1-2-3-4) every minute and until complete recovery thereafter.…”

Section: Methodsmentioning

confidence: 99%

“…A better understanding of gastroesophageal changes during nausea requires a nonpharmacological nausea induction method and less invasive techniques to assess gastric and esophageal behavior. Nausea can be provoked effectively by viewing a motion video of a rotating and tilted landscape (3,32). Unlike barostat, high-resolution manometry (HRM) allows minimal invasive, detailed measurements of fundus pressure (FP) and axial movement of the gastroesophageal junction (GEJ) (19,20,30).…”

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confidence: 99%

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Gastric and lower esophageal sphincter pressures during nausea: a study using visual motion-induced nausea and high-resolution manometry

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Kuo

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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Nausea is the subjective unpleasant sensation that immediately precedes vomiting. Studies using barostats suggest that gastric fundus and lower esophageal sphincter (LES) relaxation precede vomiting. Unlike barostat, high-resolution manometry allows less invasive, detailed measurements of fundus pressure (FP) and axial movement of the gastroesophageal junction (GEJ). Nausea was induced in 12 healthy volunteers by a motion video and rated on a visual analog scale. FP was measured as the mean value of the five pressure channels that were clearly positioned below the LES. After intubation, a baseline (BL) recording of 15 min was obtained. This was followed by presentation of the motion video (at least 10 min, maximum 20 min) followed by 30 min recovery recording. Throughout the experiment we recorded autonomic nervous system (ANS) parameters [blood pressure, heart rate (HR), and cardiac vagal tone (CVT), which reflects efferent vagal activity]. Ten out of 12 subjects showed a drop in FP during peak nausea compared with BL (-4.0 ± 0.8 mmHg; P = 0.005), and 8/10 subjects showed a drop in LES pressure (-8.8 ± 2.5 mmHg; P = 0.04). Peak nausea preceded peak fundus and LES pressure drop. Nausea was associated with configuration changes at the GEJ such as LES shortening and esophageal lengthening. During nausea we observed a significantly increased HR and decreased CVT. In conclusion, nausea is associated with a drop in fundus and LES pressure, configuration changes at the GEJ as well as changes in the ANS activity such as an increased sympathetic tone (increased HR) and decreased parasympathetic tone (decreased CVT).

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%