Sub-zero microRNA expression in the liver of the frozen hatchling painted turtle, Chrysemys picta marginata

Varma, Anchal; Breedon, Sarah A; Storey, Kenneth B.

doi:10.1016/j.scitotenv.2022.159304

Cited by 4 publications

(3 citation statements)

References 64 publications

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“…Another study showed that the DEGs in the liver that were enriched in NF-κB signaling pathway played certain protective roles in Chinese Strip-necked Turtle ( Mauremys sinensis ) under ammonia exposure [ 23 ]. Recent research has shown 17 up-regulated and 13 down-regulated miRNAs to play important roles in the down-regulation of central metabolic processes and maintenance of tissue homeostasis in response to freezing stress in the Midland painted turtle ( Chrysemys picta marginata ) liver tissue [ 24 ]. In the present study, we focused on the effect of noise stress on turtles and found that noise caused significant changes in the expression of 176 genes in the livers of T .…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of the liver transcriptome in the red-eared slider (Trachemys scripta elegans) post exposure to noise

Ma,

Zuo,

et al. 2024

PLoS ONE

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Exposure to noise can cause non-auditory health problems and has been widely studied in mammals such as rats and rabbits. However, the non-auditory effects of noise exposure on reptiles (such as red-eared sliders) remain unclear. In this study, we determined the noise exposure-induced transcriptomic changes in the liver of red-eared slider (Trachemys scripta elegans) using Illumina Novaseq6000 sequencing technology. The transcriptome analysis identified 176 differentially expressed genes (DEGs), which were mainly enriched in lipid metabolism. KEGG analysis showed that by affecting the peroxisome proliferator activated receptor (PPAR) signaling pathway these DEGs increased lipid synthesis and decreased lipid oxidation. The Oil Red O staining results validated our data that noise exposure increased hepatic lipid deposition. Thus, noise exposure may lead to lipid accumulation and toxicity, mitochondrial damage, and accelerated oxidative stress. Our findings provide insights into the molecular process underlying non-auditory damage caused by noise exposure in T. scripta elegans.

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Section: Discussionmentioning

confidence: 99%

Comparative analysis of the liver transcriptome in the red-eared slider (Trachemys scripta elegans) post exposure to noise

Ma,

Zuo,

et al. 2024

PLoS ONE

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“…35,36 Many previous studies have implicated differential miRNA regulation and expression during MRD in various animals exposed to a variety of environmental stresses. [37][38][39][40][41][42][43][44][45] These findings underscore the critical role miRNAs play in regulating gene expression to facilitate stress tolerance across vast species.…”

Section: Introductionmentioning

confidence: 87%

“…Additionally, miRNA expression is known to change in response to external stimuli, including extreme environmental stress 35,36 . Many previous studies have implicated differential miRNA regulation and expression during MRD in various animals exposed to a variety of environmental stresses 37–45 . These findings underscore the critical role miRNAs play in regulating gene expression to facilitate stress tolerance across vast species.…”

Section: Introductionmentioning

confidence: 94%

Torpor‐responsive microRNAs in the heart of the Monito del monte, Dromiciops gliroides

et al. 2023

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The marsupial Monito del monte (Dromiciops gliroides) utilizes both daily and seasonal bouts of torpor to preserve energy and prolong survival during periods of cold and unpredictable food availability. Torpor involves changes in cellular metabolism, including specific changes to gene expression that is coordinated in part, by the posttranscriptional gene silencing activity of microRNAs (miRNA). Previously, differential miRNA expression has been identified in D. gliroides liver and skeletal muscle; however, miRNAs in the heart of Monito del monte remained unstudied. In this study, the expression of 82 miRNAs was assessed in the hearts of active and torpid D. gliroides, finding that 14 were significantly differentially expressed during torpor. These 14 miRNAs were then used in bioinformatic analyses to identify Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways that were predicted to be most affected by these differentially expressed miRNAs. Overexpressed miRNAs were predicted to primarily regulate glycosaminoglycan biosynthesis, along with various signaling pathways such as Phosphoinositide‐3‐kinase/protein kinase B and transforming growth factor‐β. Similarly, signaling pathways including phosphatidylinositol and Hippo were predicted to be regulated by the underexpression of miRNAs during torpor. Together, these results suggest potential molecular adaptations that protect against irreversible tissue damage and enable continued cardiac and vascular function despite hypothermia and limited organ perfusion during torpor.

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Cardiac microRNA expression profile in response to estivation

2023

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Sub-zero microRNA expression in the liver of the frozen hatchling painted turtle, Chrysemys picta marginata

Cited by 4 publications

References 64 publications

Comparative analysis of the liver transcriptome in the red-eared slider (Trachemys scripta elegans) post exposure to noise

Comparative analysis of the liver transcriptome in the red-eared slider (Trachemys scripta elegans) post exposure to noise

Torpor‐responsive microRNAs in the heart of the Monito del monte, Dromiciops gliroides

Cardiac microRNA expression profile in response to estivation

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