2022
DOI: 10.1007/s00018-022-04188-3
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Subcellular progression of mesenchymal transition identified by two discrete synchronous cell lines derived from the same glioblastoma

Abstract: Glioblastomas (GBM) exhibit intratumoral heterogeneity of various oncogenic evolutional processes. We have successfully isolated and established two distinct cancer cell lines with different morphological and biological characteristics that were derived from the same tissue sample of a GBM. When we compared their genomic and transcriptomic characteristics, each cell line harbored distinct mutation clusters while sharing core driver mutations. Transcriptomic analysis revealed that one cell line was undergoing a… Show more

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Cited by 2 publications
(1 citation statement)
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“…GBM cells may also migrate via the epithelial-mesenchymal transition mechanism, supported by a very low expression of E-cadherin, functioning for cell-cell adhesion and contact prevention of migration [26]. It was also shown that epithelial-mesenchymal transition is activated in some GBM clones, which correlated with a poorer prognosis and a more aggressive tumor phenotype [27].…”
Section: Glioblastomamentioning
confidence: 99%
“…GBM cells may also migrate via the epithelial-mesenchymal transition mechanism, supported by a very low expression of E-cadherin, functioning for cell-cell adhesion and contact prevention of migration [26]. It was also shown that epithelial-mesenchymal transition is activated in some GBM clones, which correlated with a poorer prognosis and a more aggressive tumor phenotype [27].…”
Section: Glioblastomamentioning
confidence: 99%