Subchronic mycotoxicoses in Wistar rats: Assessment of the in vivo and in vitro genotoxicity induced by fumonisins and aflatoxin B1, and oxidative stress biomarkers status

Protective Effects of Lactobacillus rhamnosus GG on Aflatoxins-Induced Toxicities in Male Albino Mice

“…AFB 1 genotoxicity might be caused through the formation of AFB 1 -DNA adducts, which is regarded as a critical step in the initiation of AFB 1 -induced hepatocarcinogenesis [9,10]. Moreover, several reports suggested that oxidative stress is considered to be related to cell injury and DNA damage induced by AFB 1 through the generation of intracellular reactive oxygen species (ROS) [12,16] In contradiction, the present results showed that the administration of LGG before AFs-intoxication reduced the AFs-induced genotoxicity (somatic and germ cells by around three folds) and cytotoxicity in both cell types. These data are consistent with other experimental studies which had evidenced the ability of lactobacilli and bifidobacteria to decrease the genotoxic activity of some chemical compounds [32,77,78].…”

Aflatoxin B1 - Prevention of Its Genetic Damage by Means of Chemical Agents

“…The formed epoxide is very unstable in water but can be handled relatively easily in aprotic solvents. CYP enzymes, on the other hand, also oxidize AFB1 to deactivated products that are generally poor substrates for epoxidation, or to those which after that step do not interact with DNA, including AFM, AFQ, and the endo-epoxide (Johnson & Guengerich, 1997;Guengerich et al, 1998 Anwar et al, 1994;El-Zawahri et al, 1990;Le Hegarat et al, 2010;Miranda et al, 2007;Theumer et al, 2010). The above mentioned genotoxicity is in line with the induction of cancer by aflatoxins.…”

Assessment of Genotoxic and Cytogenetic Effects of Aflatoxin B1 in Mouse Bone Marrow Cells

“…Continued exposure to AFB1 results in stunted growth, mutagenicity, genotoxicity, and immunosuppression. It also caused an increasing hepatocellular carcinoma (HCC) incidence in humans and animals (Theumer et al, 2010;Abbes et al, 2010;Sun et al, 2011). Aflatoxin B1 works synergistically with some human health factors such as hepatitis B virus infection, nutritional status, sex, age and the amount of AFs exposure to initiate the development of cancer (Qureshi et al, 2014;Wild and Montesano, 2009).…”