Subchronic oral toxicity studies with α-cyclodextrin in rats

Lina, B.A.R.; Bär, A.

doi:10.1016/j.yrtph.2004.05.006

Cited by 36 publications

(22 citation statements)

References 22 publications

(19 reference statements)

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“…FBCx (generically known as a-cyclodextrin; Wacker Biochem, Adrian, MI) is a soluble fiber derived from corn. The World Health Organization has given it an acceptable daily intake of bnot specified.Q Furthermore, based on the safety data presented [18][19][20][21], this material was recently granted Generally Recognized As Safe status by the FDA. FBCx has been shown to bind with free fatty acids in aqueous solution [22].…”

Section: Introductionmentioning

confidence: 99%

The effects of a new soluble dietary fiber on weight gain and selected blood parameters in rats

Artiss¹,

Brogan²,

Brucal³

et al. 2006

Metabolism

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Section: Introductionmentioning

confidence: 99%

The effects of a new soluble dietary fiber on weight gain and selected blood parameters in rats

Artiss¹,

Brogan²,

Brucal³

et al. 2006

Metabolism

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“…In the 13-week rat toxicity study a NOAEL of about 13 g/kg bw/d was determined. This was the highest dose level tested (Lina and B€ ar, 2004). The present study was conducted to examine the tolerance of dietary a-CD in a non-rodent species.…”

Section: Introductionmentioning

confidence: 99%

Subchronic (13-week) oral toxicity study of α-cyclodextrin in dogs

Lina

Bär²

2004

Regulatory Toxicology and Pharmacology

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“…HPLC analyses in duplicate of five samples of every test diet demonstrated that the mixtures were homogeneous and that the actual and nominal a-CD levels were similar (deviations of )9, )18, )5, and )4% were found in the feed of the 1.5, 5, 10, and 20% dose group, respectively). a-CD in the test diets was known to be stable from the analytical results of another study (Lina and B€ ar, 2004a).…”

Section: Diet and Test Compoundmentioning

confidence: 95%

Embryotoxicity and teratogenicity study with α-cyclodextrin in rats

Waalkens-Berendsen

Bär²

2004

Regulatory Toxicology and Pharmacology

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The embryotoxicity/teratogenicity of alpha-cyclodextrin (alpha-CD) was examined in Wistar Crl:(WI)WU BR rats. alpha-CD was fed at dietary concentrations of 0, 1.5, 5, 10, or 20% to groups of 25 pregnant female rats from day 0 to 21 of gestation. An additional group received a diet with 20% lactose. The additions to the diet of alpha-CD and lactose were made at the expense of pregelatinized potato starch. Body weight as well as food and water intake were recorded during the treatment period. The rats were killed on day 21 and examined for standard parameters of maternal reproductive performance. The fetuses were examined for external abnormalities, body weight and crown rump length. Fetuses were examined for skeletal and visceral abnormalities. Generally, alpha-CD was well tolerated and no deaths occurred in any group. Weight gain and food consumption were similar in all groups during gestation, except for a slightly yet significantly increased food intake in the 20% alpha-CD group from day 6 to 21. Water intake was similar in all alpha-CD groups; in the lactose group, it was significantly higher than in the controls. Maternal reproductive performance was not affected by the alpha-CD treatment. Examination of the fetuses for external, visceral and skeletal changes did not reveal any fetotoxic, embryotoxic, or teratogenic effects of alpha-CD. In conclusion, no adverse effects were observed at alpha-CD intakes of up to 20% of the diet, the highest dose level tested at which the rats consumed about 13 g/kg bw/day.

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Subchronic oral toxicity studies with α-cyclodextrin in rats

Cited by 36 publications

References 22 publications

The effects of a new soluble dietary fiber on weight gain and selected blood parameters in rats

The effects of a new soluble dietary fiber on weight gain and selected blood parameters in rats

Subchronic (13-week) oral toxicity study of α-cyclodextrin in dogs

Embryotoxicity and teratogenicity study with α-cyclodextrin in rats

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