Subchronic safety evaluation of hot-water extract from thinned immature mangos (Mangifera indica ‘Irwin’): 90-days oral toxicity study in rats

Abstract

Graphical abstract Thinned Irwin mango fruits were collected at the immature stage and lyophilized. Hot-water extract from thinned immature mango (TIMEx) had no toxic effect on SD rats given daily oral doses of 500, 1000 or 2500 mg/kg for 90 days. No significant alterations in hematological and serum chemical parameters, urinalysis, food consumption, body weight gain, or absolute and relative organ weights were noted in any group. In both sexes, a daily dose up to 2500 mg/kg body weight indicates a NOAEL.

Ninety-day repeated oral toxicity study of saponified Capsicum annum fruit extract with 50% capsanthin in Sprague-Dawley Rats with a 28-day recovery period

“…In this study, the hematology and blood chemistry parameters were selected based on the rat study reported by Tajri H et al [18] . All the animals were kept in a biologic cage and blood samples were collected in the early morning between 7.00 and 9.00AM to reduce biological variation caused by circadian rhythms from all animals at the end of the experiment period under fasting conditions at least for 14 h but allowed access to water ad libitum.…”