Subclass restriction pattern of antigen-specific antibodies in donors with defective expression of IgG or IgA subclass heavy chain constant region genes

Hammarström, Lennart; Carbonara, A. O.; DeMarchi, M; Lefranc, Gérard; Möller, Göran; Smith, C. I. Edvard; Zegers, B. J. M.

doi:10.1016/0090-1229(87)90097-3

Cited by 17 publications

(12 citation statements)

References 21 publications

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“…The heavy chain isotype of serum antibody directed against PA is primarily IgG1. Serum antibodies directed against protein antigens are in general dominated by the IgG1 isotype (Hammarstrom et al, 1987;Papadea and Check, 1989). Thirty-one of the 35 paratopes reported herein are also IgG1 in concordance with this fact.…”

Section: Class Switch Recombinationsupporting

confidence: 79%

Paratope diversity in the human antibody response to Bacillus anthracis protective antigen

Zhou¹,

Ullal²,

Liberato³

et al. 2008

Molecular Immunology

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The active component of the licensed human anthrax vaccine (BioThrax™, or AVA) is a Bacillus anthracis toxin known as protective antigen (PA). Second generation anthrax vaccines currently under development are also based on a recombinant form of PA. Since the current and future anthrax vaccines are based on this toxin, it is important that the immunobiology of this protein in vaccinated humans be understood in detail. We have isolated and analyzed the PA-specific antibody repertoire from an AVA-vaccinated individual. When examined at the clonal level, we find an antibody response that is complex in terms of the combinatorial elements and immunoglobulin variable genes employed. All PA-specific antibodies had undergone somatic hypermutation and class switch recombination, both signs of affinity maturation. Although the antigenic epitopes recognized by the response were distributed throughout the PA monomer, the majority of antibodies arising in this individual following vaccination recognize determinants located on the amino-terminal (PA 20) subdomain of the molecule. This latter finding may have implications for the rational design of future PA-based anthrax vaccines.

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Section: Class Switch Recombinationsupporting

confidence: 79%

Paratope diversity in the human antibody response to Bacillus anthracis protective antigen

Zhou¹,

Ullal²,

Liberato³

et al. 2008

Molecular Immunology

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“…In our study, only 15% (2/13) of IgAdeficient individuals with severe infections were IgG2-deficient. Furthermore, the IgG2 subclass by no means contains all serum antibodies to polysaccharide antigens; IgG2 deficiency may be compensated for by other immunoglobulin classes or IgG subclasses [20,21]. As our results indicate, severe infections in IgA-deficient individuals are more strongly correlated with a deficiency of IgG4 than of IgG2 (54% versus 15%).…”

Section: Discussionsupporting

confidence: 66%

Severity of infections in IgA deficiency: correlation with decreased serum antibodies to pneumococcal polysaccharides and decreased serum IgG2 and/or IgG4

French

Denis

Dawkins

et al. 1995

Clinical and Experimental Immunology

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SUMMARY In order to define abnormalities of humoral immunity which determine susceptibility to respiratory tract infections in IgA‐deficient adults, serum IgG subclass concentrations, and serum concentrations of pneumococcal antibodies and Haemophilus influenzae type B (Hib) antibodies sera from IgA‐deficient adults with and without susceptibility to respiratory tract infections were compared. Infection susceptibility was not related to the degree of IgA deficiency, but was related to deficiency of IgG4 and, to a lesser extent, IgG2, as well as to low basal serum concentrations of pneumococcal polysaccharide antibodies. The combination of IgG2 and/or IgG4 deficiency and a non‐protective basal serum concentration of antibody against two or more pneumococcal polysaccharides was present in the serum of six of 12 (50%) patients with severe infections, but only one of 44 (2%) patients without infections. Furthermore, the preservation of antibody responses against the most immunogenic pneumococcal polysaccharide type 3, but not against the less immunogenic types 7F, 9N and 14, in patients with severe infections suggested that abnormalities of pneumococcal polysaccharide antibody responses might include defects of affinity maturation.

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“…In one study, IgG1 in seven commercial intravenous IgG preparations contained nearly as much antipneumococcal antibody as IgG2 on a per-milligram-ofIgG-subclass basis [28]. Anti-pneumococcal polysaccharide antibodies of the IgG1 and IgG3 subclasses occur in persons who have IgA deficiency [29] or heavy chain constant region deletions of the 2 gene [30,31]. IgG1 anti-Hib polysaccharide from adults killed Hib more effectively in vitro than IgG2 [32].…”

Section: Discussionmentioning

confidence: 99%

Selective subnormal IgG3 in 121 adult index patients with frequent or severe bacterial respiratory tract infections

Barton

Bertoli²,

Acton

2016

Cellular Immunology

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Subclass restriction pattern of antigen-specific antibodies in donors with defective expression of IgG or IgA subclass heavy chain constant region genes

Cited by 17 publications

References 21 publications

Paratope diversity in the human antibody response to Bacillus anthracis protective antigen

Paratope diversity in the human antibody response to Bacillus anthracis protective antigen

Severity of infections in IgA deficiency: correlation with decreased serum antibodies to pneumococcal polysaccharides and decreased serum IgG2 and/or IgG4

Selective subnormal IgG3 in 121 adult index patients with frequent or severe bacterial respiratory tract infections

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