Subclinical atherosclerosis evolution during 5 years of anti-TNF-alpha treatment in psoriatic arthritis patients

Ortolan, Augusta; Ramonda, Roberta; Lorenzin, Mariagrazia; Pesavento, Raffaele; Spinazzè, Alice; Felicetti, Mara; Nardin, Chiara; Rattazzi, Marcello; Doria, Andrea; Puato, Massimo

doi:10.55563/clinexprheumatol/3qiqk3

Cited by 13 publications

(4 citation statements)

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“…Thus, changes in cell shape leading to reorganization of actin cytoskeleton can regulate growth and proliferation, making cytoskeleton regulation a potential intervention for atherosclerosis 31 . TNF, one of the proinflammatory cytokines, play an important role in the pathophysiology of the inflammatory arthritis including gout and are associated with the induction and maintenance of the atherosclerosis 32 , 33 .Two studies reported that TNF antagonists may have a beneficial effect on preventing the progression of subclinical atherosclerosis 33 , 34 . Wei Gao et al discovered the underlying mechanism and found that exosomes derived from mature dendritic cells increase atherosclerosis via membrane TNF mediated NF-kB pathway 35 .…”

Section: Discussionmentioning

confidence: 99%

Identification of hub genes and transcription factors in patients with primary gout complicated with atherosclerosis

Xiao,

Lin,

Zhan

2024

Sci Rep

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Evidence shows that primary gout is prone to develop to atherosclerosis, but the mechanism of its occurrence is still not fully clarified. The aim of this study was to explore the molecular mechanism of the occurrence of this complication in gout. The gene expression profiles of primary gout and atherosclerosis were downloaded from the gene expression omnibus database. Overlapping differentially expressed genes (DEGs) between gout and atherosclerosis were identified. The biological roles of common DEGs were explored through enrichment analyses. Hub genes were identified using protein–protein interaction networks. The immune infiltrations of 28 types of immune cells in gout and control samples from GSE160170 were evaluated by the ssGSEA method. Transcription factors (TFs) were predicted using Transcriptional Regulatory Relationships Unraveled by Sentence Based Text Mining (TRRUST) database. A total of 168 overlapping DEGs were identified. Functional enrichment analyses indicated that DEGs were mostly enriched in chemokine signaling pathway, regulation of actin cytoskeleton, and TNF signaling pathway. CytoScape demonstrated 11 hub genes and two gene cluster modules. The immune infiltration analysis showed that the expression of DEGs in gout was significantly upregulated in activated CD4 T cells, gamma delta T cells, T follicular helper cell, CD56dim natural killer cells, and eosinophil. TRRUST predicted one TF, RUNX family transcription factor 1. Our study explored the pathogenesis of gout with atherosclerosis and discovered the immune infiltration of gout. These results may guide future experimental research and clinical transformation.

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Section: Discussionmentioning

confidence: 99%

Identification of hub genes and transcription factors in patients with primary gout complicated with atherosclerosis

Xiao,

Lin,

Zhan

2024

Sci Rep

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“…Moreover, human studies have demonstrated that both coronary artery and circulating IL-32 levels were elevated in CAD patients, suggesting that IL-32 was independently related to the existence of CAD and could have played a role in atherosclerotic CAD through modulating the inflammatory response [39]. A recent study on evaluating subclinical atherosclerosis progression after 5 years of anti-TNF-α treatment in psoriatic arthritis patients showed a slight progression of subclinical atherosclerosis in the first 2 years of anti-TNF-α treatment [40]. A study by Puz et al [41] corroborated that TNF-α and IL-6 were involved in atherosclerosis development in patients with internal carotid artery stenosis.…”

Section: Discussionmentioning

confidence: 99%

The Serum Levels of IL-36 in Patients with Coronary Artery Disease and Their Correlation with the Serum Levels of IL-32, IL-6, TNF-α, and Oxidative Stress

Kazemian¹,

Ahmadi²,

Rafiei³

et al. 2022

Int Arch Allergy Immunol

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Introduction: Atherosclerosis is a chronic inflammatory process maintained during all stages of the disease by several proinflammatory mediators, such as cytokines and chemokines. Interleukin (IL)-36 cytokines are proinflammatory and have an essential role in innate and adaptive immunity, but the role of IL-36 has not been determined in coronary artery disease (CAD). This study aimed to measure the serum levels of IL-36 in patients with CAD and their association with the serum levels of tumor necrosis factor (TNF)-α, IL-6, and IL-32 and also investigate their correlation with the serum levels of malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP). Methods: A total of 168 subjects (84 CAD and 84 control subjects) were examined in this research. The total serum levels of IL-36 were measured using the enzyme-linked immunosorbent assay (ELISA). Also, some oxidative stress parameters were evaluated by FRAP and MDA assays in the serum. Results: The serum levels of IL-36 and MDA were significantly higher, and FRAP was significantly lower in the CAD group compared to the controls. Furthermore, the serum levels of IL-36, MDA, and FRAP significantly correlated with the CAD group’s cardiac arterial stenosis. Also, the serum levels of IL-36 had a positive and significant correlation with the serum levels of TNF-α, IL-6, IL-32, and biochemical parameters in the CAD group. Conclusion: Higher serum levels of IL-36 and its association with the serum levels of TNF-α, IL-32, and IL-6 may play a key role in the pathogenesis of CAD, leading to an increased risk of clogged arteries and oxidative stress.

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“…It is possible that CRP and IL-6 are related to CVD outcomes but less related to subclinical disease 35 or resilient to dietary challenges 36 . Pro-inflammatory cytokines, such as TNFα, are widely known to be atherogenic 21 , but studies on the efficacy of TNFα inhibitors to stall progression of SA in high-risk patients has been controversial 37 , 38 . Some studies also reported an association between presence of atherosclerotic plaque with TNFα receptors, but absence of association with TNFα itself 35 .…”

Section: Discussionmentioning

confidence: 99%

Gender differences in fasting and postprandial metabolic traits predictive of subclinical atherosclerosis in an asymptomatic Chinese population

Loh

Sun

Allen

et al. 2022

Sci Rep

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The prediction utility of Framingham Risk Score in populations with low conventional cardiovascular risk burden is limited, particularly among women. Gender-specific markers to predict cardiovascular risk in overtly healthy people are lacking. In this study we hypothesize that postprandial responses triggered by a high-calorie meal test differ by gender in their ability to triage asymptomatic subjects into those with and without subclinical atherosclerosis. A total of 101 healthy Chinese subjects (46 females, 55 males) at low risk of coronary heart disease completed the study. Subjects underwent cardiovascular imaging and postprandial blood phenotyping after consuming a standardized macronutrient meal. Prediction models were developed using logistic regression and subsequently subjected to cross-validation to obtain a de-optimized receiver operating characteristic (ROC) curve. Distinctive gender differences in postprandial trajectories of glucose, lipids and inflammatory markers were observed. We used gender-specific association with different combinations of postprandial predictors to develop 2 models for predicting risk of subclinical atherosclerosis in males (ROC AUC = 0.7867, 95% CI 0.6567, 0.9166) and females (ROC AUC = 0.9161, 95% CI 0.8340, 0.9982) respectively. We report novel postprandial models for predicting subclinical atherosclerosis in apparently healthy Asian subjects using a gender-specific approach, complementing the conventional Framingham Risk Score.Clinical Trial Registration: The trial was registered at clinicaltrials.gov as NCT03531879.

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Subclinical atherosclerosis evolution during 5 years of anti-TNF-alpha treatment in psoriatic arthritis patients

Cited by 13 publications

References 0 publications

Identification of hub genes and transcription factors in patients with primary gout complicated with atherosclerosis

Identification of hub genes and transcription factors in patients with primary gout complicated with atherosclerosis

The Serum Levels of IL-36 in Patients with Coronary Artery Disease and Their Correlation with the Serum Levels of IL-32, IL-6, TNF-α, and Oxidative Stress

Gender differences in fasting and postprandial metabolic traits predictive of subclinical atherosclerosis in an asymptomatic Chinese population

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