Subclinical cardiovascular changes in pediatric solid organ transplant recipients

Incidence and magnitude of post‐transplant cardiovascular disease after pediatric kidney transplantation: Risk factor analysis of 1058 pediatric kidney transplants at the university of Minnesota

“…Even then, because these patients have a significantly longer life expectancy than adult KT recipients, the propensity for early discovery and reduction of CVD manifestations on this population is of greater importance. While transplant care—immunosuppression, rejection and infection surveillance, cancer screening, renal function, and blood pressure management—in these patients is much more comprehensive, the overlap between disciplinary lines is less exhaustive for cardiovascular screening and health maintenance . Thus, in moving forward, the programmatic schema for the reduction in CVEs in pediatric KT recipients must entail aggressive implementation of conventional treatment and surveillance guidelines such as frequent cardiac rhythm assessment, low dose aspirin, and statin administration.…”

“…While transplant care-immunosuppression, rejection and infection surveillance, cancer screening, renal function, and blood pressure management-in these patients is much more comprehensive, the overlap between disciplinary lines is less exhaustive for cardiovascular screening and health maintenance. 29,30 Thus, in moving forward, the programmatic schema for the reduction in There are a number of limitations with our study. This is a single-center study that is limited to center-specific populations and treatment practices.…”

The ongoing need to improve long‐term patient survival of pediatric solid organ recipients

“…9 Allograft dysfunction in kidney transplant recipients and chronic kidney disease in other SOT recipients are major risk factors for this cardiovascular risk. 10 Apart from conventional risk factors, one possible explanation for allograft dysfunction contributing to cardiovascular morbidity could be the massive accumulation of sodium in the skin and muscle, which exceeds the natural accumulation of sodium throughout life. 11,12 The relatively good 20-year patient survival in kidney recipients in Finland is remarkable, given that a pediatric sodium MRI study found the highest skin and muscle sodium concentrations in patients with focal segmental glomerulosclerosis and CNS.…”

“…Allograft dysfunction in kidney transplant recipients and chronic kidney disease in other SOT recipients are major risk factors for this cardiovascular risk 10 . Apart from conventional risk factors, one possible explanation for allograft dysfunction contributing to cardiovascular morbidity could be the massive accumulation of sodium in the skin and muscle, which exceeds the natural accumulation of sodium throughout life 11,12 .…”