Subclinical diastolic dysfunction in children with Wilson’s disease assessed by tissue Doppler echocardiography: a possible early predictor of cardiac involvement

Elkiran, Ozlem; Karakurt, Cemşit; Selimoğlu, Ayşe; Karabi̇ber, Hamza; Koçak, Gülendam; Çelik, Şenol; Çolak, Cemil

doi:10.1080/ac.68.2.2967276

Cited by 17 publications

(14 citation statements)

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“…4,21 The study by Arat et al showed that left ventricular wall thickness, left ventricular diameter and left ventricular ejection fraction were similar in both Wilson's patients and the control group. 3 The similar results were published by Elkiran et al and Hlubocka et al 22,23 We suggested that, even though patients in these studies are mostly well treated and had neither severe neurological impairment nor cardiac symptoms, a more comprehensive investigation is needed to evaluate cardiac involvement in a totally asymptomatic patient group. Tissue Doppler echocardiography is a more useful echocardiographic technique to evaluate global and regional myocardial systolic as well as diastolic function when compared to standard echocardiography, particularly for the assessment of asymptomatic patients.…”

Section: Discussionsupporting

confidence: 79%

Assessment of cardiac function and electrocardiographic findings in patients with Wilson’s disease

et al. 2019

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Background:This study evaluated cardiac function using tissue Doppler echocardiography and assessed electrocardiographic findings in children diagnosed with Wilson’s disease.Method:Asymptomatic patients with a diagnosis of Wilson’s disease (n = 43) were compared to healthy controls (n = 37) that were age and gender matched.Results:The standard electrocardiographic and conventional echocardiographic examinations were similar in both groups. The left ventricular ejection fraction, shortening fraction, and diastolic function were not significantly different between the two groups. The Tei index for mitral lateral, mitral septal, tricuspid lateral, tricuspid septal, and inter-ventricular septum on tissue Doppler echocardiography was higher in the patient group, yet it did not reach statistical significance. Mitral lateral and septal systolic annular velocity values were significantly lower in the patient group when compared to the control group (p = 0.02 and 0.04, respectively). Also, mitral lateral and septal isovolumetric contraction time values were higher in the patient group (p = 0.04). Although the left ventricular values were not significantly different, relative left ventricular wall thickness was higher in the patient group when compared to the control group, and concentric remodelling in the left ventricle was found in 7 (16%) of 42 patients. QT interval (p = 0.02) and P-wave dispersion values (p = 0.04) were significantly higher in the patient group compared to the control group, and these tend to predict arrhythmias.Conclusion:Our study based on the tissue Doppler echocardiography assessment indicated a subclinical systolic, rather than diastolic, dysfunction in the myocardium with increased QT interval and P-wave dispersion, despite the young age of the patients and short disease duration.

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Section: Discussionsupporting

confidence: 79%

Assessment of cardiac function and electrocardiographic findings in patients with Wilson’s disease

et al. 2019

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“…We previously evaluated 22 children with Wilson’s disease with 24-hour ECG monitoring and our study showed that one patient had first-degree atrioventricular block, one had frequent sinus exit block, and four had rare ventricular ectopic beat 8. In our study, all the patients were assessed with ECG before echocardiographic evaluation.…”

Section: Discussionmentioning

confidence: 95%

Strain and strain rate echocardiography in children with Wilson’s disease

Karakurt

Çelik

Selimoğlu

et al. 2016

CVJA

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SummaryObjectiveThis study aimed to evaluate strain and strain rate echocardiography in children with Wilson’s disease to detect early cardiac dysfunction.MethodsIn this study, 21 patients with Wilson’s disease and a control group of 20 age- and gender-matched healthy children were included. All the patients and the control group were evaluated with two-dimensional (2D) and colour-coded conventional transthoracic echocardiography by the same paediatric cardiologist using the same echocardiography machine (Vivid E9, GE Healthcare, Norway) in standard precordial positions, according to the American Society of Echocardiography recommendations. 2D strain and strain rate echocardiography were performed after the ECG probes of the echocardiography machine were adjusted for ECG monitoring. Longitudinal, transverse and radial strain, and strain rate were assessed from six basal and six mid-ventricular segments of the left ventricle, as recommended by the American Society of Echocardiography.ResultsLeft ventricular wall thickness, systolic and diastolic diameters, left ventricular diameters normalised to body surface area, end-systolic and end-diastolic volumes, cardiac output and cardiac index values were within normal limits and statistically similar in the patient and control groups (p < 0.05).Global strain and strain rate: the patient group had a statistically significant lower peak A longitudinal velocity of the left basal point and peak E longitudinal velocity of the left basal (VAbasR) point, and higher global peak A longitudinal/circumferential strain rate (GSRa) compared to the corresponding values of the control group (p < 0.05).Radial strain and strain rate: end-systolic rotation [ROT (ES)] was statistically significantly lower in the patient group (p < 0.05). Longitudinal strain and strain rate: end-systolic longitudinal strain [SLSC (ES)] and positive peak transverse strain (STSR peak P) were statistically significantly lower in the patient group (p < 0.05).Segmental analysis showed that rotational strain measurement of the anterior and lateral segments of the patient group were statistically significantly lower than the corresponding values of the control group (p < 0.05). Segmental analysis showed statistically significantly lower values of end-systolic longitudinal strain [STSR (ES)] of the basal lateral (p < 0.05) and end-systolic longitudinal strain [SLSC (ES)] of the basal septal segment (p < 0.05) in the patient group.End-systolic longitudinal strain [SLSC (ES)] and positive peak transverse strain (STSR peak P) were statistically significantly lower in the patient group (p < 0.05). Segmental analysis showed statistically significantly lower values of endsystolic longitudinal strain [SLSC (ES)] of the mid-anterior and basal anterior segments (p < 0.05), end-systolic longitudinal strain [STSR (ES)] measurements of the posterior and mid-posterior segments, end-systolic longitudinal displacement [DLDC (ES)] of the basal posterior, mid-posterior and mid-antero-septal segments in the patient group.Conclusion...

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“…Recently, the use of Doppler echocardiography in children with various diseases has showed the presence of diastolic dysfunction. In particular, tissue Doppler echocardiography has been efficiently performed to establish adverse cardiac effects in the subclinical states . Impaired left ventricular function has been documented in asymptomatic diabetic patients and diastolic dysfunction is the first stage of diabetic cardiomyopathy .…”

Section: Introductionmentioning

confidence: 99%

Can ambulatory blood pressure monitoring detect early diastolic dysfunction in children with type 1 diabetes mellitus: correlations with B-type natriuretic peptide and tissue Doppler findings

et al. 2014

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Subclinical diastolic dysfunction in children with Wilson’s disease assessed by tissue Doppler echocardiography: a possible early predictor of cardiac involvement

Abstract: Our study showed results that might be consistent with disease children which probably represents an early stage of cardiac involvem the patients.

Cited by 17 publications

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Assessment of cardiac function and electrocardiographic findings in patients with Wilson’s disease

Assessment of cardiac function and electrocardiographic findings in patients with Wilson’s disease

Strain and strain rate echocardiography in children with Wilson’s disease

Can ambulatory blood pressure monitoring detect early diastolic dysfunction in children with type 1 diabetes mellitus: correlations with B-type natriuretic peptide and tissue Doppler findings

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