Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: a multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms

Abstract

In young adults with T2DM, diabetes duration and aortic distensibility were associated with diastolic dysfunction. Interventional studies are required to assess whether cardiac dysfunction can be reversed in this phenotype of patients.

Native T1 reference values for nonischemic cardiomyopathies and populations with increased cardiovascular risk: A systematic review and meta‐analysis

“…1. A total of ten studies were included for the HCM group, 17,29-37 nine for DCM, 11,30,33,35,[38][39][40][41][42] twelve in MC, 30,[43][44][45][46][47][48][49][50][51][52][53] five in iron overload, 54-58 six in amyloidosis, 32,[59][60][61][62][63] two in Fabry disease, 64,65 ten in HT, 13,17,34,37,[66][67][68][69][70][71] four in DM, [72][73][74][75] and one in obesity 74 ( Table 1). The field strength is known to influence the T 1 values significantly 65 ; therefore, results from studies performed on a 1.5T or 3T are shown separately, but used as covariant in the meta-regression analysis.…”

“…Two studies reported clearly decreased T 1 values for DM, but had no healthy control population to compare them with. A reason for this decrease might be that DM patients are known to develop myocardial steatosis due to their insulin resistance, and the associated myocardial fat lowers the native T 1 value . However, the fat content of this myocardial steatosis is much smaller than in Fabry disease, and the number and size of T 1 mapping studies was too small to determine the influencing factors in this population.…”

“…However, the fat content of this myocardial steatosis is much smaller than in Fabry disease, and the number and size of T 1 mapping studies was too small to determine the influencing factors in this population. Two other studies reported much higher T 1 for DM patients and compared them with healthy controls, but both showed no significant change . Levelt et al used healthy control subjects with a BMI of 28.6 ± 5.7, which raises the question whether healthy controls should have a healthy weight (BMI <25).…”

“…DM and obese patient populations are studied less extensively with T 1 -mapping compared with the above-mentioned diseases. The weighted mean MOLLI T 1 value measured on 1.5T was 853 6 202 msec for DM patients, 72-74 963 6 116 msec for obesity subjects and 986 6 87 msec for controls 74 (Table 1, Fig. 2).…”

Comparison of global myocardial strain assessed by cardiovascular magnetic resonance tagging and feature tracking to infarct size at predicting remodelling following STEMI

“…Myocardial tissue tagging has traditionally been regarded as the reference method for the quantification of peak systolic strain [11, 12]. Feature Tracking (FT) is a novel post-processing strain quantification technique that can be performed on routinely acquired steady-state free precession cine sequences.…”