Subclinical hypothyroidism and myocardial function in obese children

Brienza, Carmine; Grandone, Anna; Salvo, Giovanni Di; Corona, Alberto; Sessa, Anna Di; Pascotto, Claudicéia Risso; Calabrò, Raffaele; Toraldo, R; Perrone, Laura; Giudice, Emanuele Miraglia del

doi:10.1016/j.numecd.2012.04.006

Cited by 22 publications

(24 citation statements)

References 25 publications

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“…In routine clinical practice, MAPSE is usually measured echocardiographically on the lateral annular site. In the current literature, to date there is no consensus on the best site to measure MAPSE [5][6][7][8]. Using CMR-derived MAPSE measurements, we obtained a slightly better intraand inter-observer reproducibility compared to previous echocardiography studies [23].…”

Section: Discussionmentioning

confidence: 59%

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Mitral annular plane systolic excursion is an easy tool for fibrosis detection by late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Doesch

Sperb

Sudarski³

et al. 2015

Archives of Cardiovascular Diseases

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MAPSE measurement using CMR is feasible, reproducible and comparable to echocardiography in healthy controls and patients with HCM. The asymmetric and mainly septal distribution of myocardial hypertrophy and fibrosis detected by LGE in patients with HCM was reflected by significantly reduced septal versus lateral MAPSE. Therefore, reduced MAPSE seems to be an easily determinable marker of fibrosis accumulation leading to left ventricular mechanical dysfunction and also seems to have a prognostic implication.

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Section: Discussionmentioning

confidence: 59%

“…MAPSE can be determined either on the lateral [6,7] or septal annular site [8] or is given as the average between the measurements at the septal and lateral annular site [5].…”

Section: Introductionmentioning

confidence: 99%

Mitral annular plane systolic excursion is an easy tool for fibrosis detection by late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Doesch

Sperb

Sudarski³

et al. 2015

Archives of Cardiovascular Diseases

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“…Several adult studies have recently shown that patients with SH had impaired myocardial contractility11 12 28–32 and diastolic dysfunction,13 28 33 which may also be reversed by L-T4 treatment 5 6 11–13 15 16. In the literature, only two studies evaluating cardiac functions of children with SH, which also have Down syndrome and obesity, are present 34 35. To our knowledge, up to now, there are no studies regarding otherwise healthy (normal weighed and non-syndromic) children with SH, which have investigated cardiac functions and potential effects of L-T4 replacement therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, impairment of these parameters was reversed after L-T4 replacement. Previously, Toscano et al 34 have investigated cardiac functions of 16 children with Down syndrome and SH (mean age, 65.5 months; mean TSH 7.8 mIU/L), and 25 healthy euthyroid children (mean age 70.3 months, mean TSH 3.2 mIU/L) by using TDE. In this study, no significant difference was determined in systolic and diastolic functions in TDE.…”

Section: Discussionmentioning

confidence: 99%

The effect of L-thyroxine treatment on left ventricular functions in children with subclinical hypothyroidism

et al. 2014

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“…Likewise, another large cohort study including over 12,000 children and adolescents showed that high serum TSH levels are significantly associated with both systolic and diastolic blood pressure, and increased the risk of hypertension in children (OR = 1.72, 95% CI = 1.15-2.57) but not in adolescents [155]. Finally, in a small case-control study, 34 obese children and adolescents with SCH were found to have significant impairment of diastolic and longitudinal systolic cardiac function on echocardiography as compared to 60 obese children with normal TSH [156]. …”

Section: Sch In Childhoodmentioning

confidence: 99%

2014 European Thyroid Association Guidelines for the Management of Subclinical Hypothyroidism in Pregnancy and in Children

Lazarus¹,

Brown²,

Daumerie³

et al. 2014

Eur Thyroid J

601

457

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This guideline has been produced as the official statement of the European Thyroid Association guideline committee. Subclinical hypothyroidism (SCH) in pregnancy is defined as a thyroid-stimulating hormone (TSH) level above the pregnancy-related reference range with a normal serum thyroxine concentration. Isolated hypothyroxinaemia (defined as a thyroxine level below the 2.5th centile of the pregnancy-related reference range with a normal TSH level) is also recognized in pregnancy. In the majority of SCH the cause is autoimmune thyroiditis but may also be due to iodine deficiency. The cause of isolated hypothyroxinaemia is usually not apparent, but iodine deficiency may be a factor. SCH and isolated hypothyroxinaemia are both associated with adverse obstetric outcomes. Levothyroxine therapy may ameliorate some of these with SCH but not in isolated hypothyroxinaemia. SCH and isolated hypothyroxinaemia are both associated with neuro-intellectual impairment of the child, but there is no evidence that maternal levothyroxine therapy improves this outcome. Targeted antenatal screening for thyroid function will miss a substantial percentage of women with thyroid dysfunction. In children SCH (serum TSH concentration >5.5-10 mU/l) normalizes in >70% and persists in the majority of the remaining patients over the subsequent 5 years, but rarely worsens. There is a lack of studies examining the impact of SCH on the neuropsychological development of children under the age of 3 years. In older children, the evidence for an association between SCH and impaired neuropsychological development is inconsistent. Good quality studies examining the effect of treatment of SCH in children are lacking.

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Subclinical hypothyroidism and myocardial function in obese children

Cited by 22 publications

References 25 publications

Mitral annular plane systolic excursion is an easy tool for fibrosis detection by late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Mitral annular plane systolic excursion is an easy tool for fibrosis detection by late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy

The effect of L-thyroxine treatment on left ventricular functions in children with subclinical hypothyroidism

2014 European Thyroid Association Guidelines for the Management of Subclinical Hypothyroidism in Pregnancy and in Children

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