Subclinical hypothyroidism and thyroid autoimmunity in women with infertility

Abalovich, Marcos; Mitelberg, Laura; Allami, Carlos; Gutiérrez, Sílvia; Alcaraz, Graciela; Otero, Patricia; Levalle, Oscar

doi:10.1080/09513590701259542

Cited by 173 publications

(115 citation statements)

References 37 publications

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“…Abalovich et al have reported endometriosis was nearly 2 times more compared to control group (25% vs 14%) and Gerhard et al reported endometriosis was nearly 5 times more (44% vs 9%). 17,33 Similarly, in patients with polycystic ovarian disease ATA positivity was significantly higher compared to control group. 42,43 Even association of this antibody positivity with premature ovarian insufficiency was also suggested.…”

Section: Autoimmune Thyroid Diseasesmentioning

confidence: 96%

“…32 Incidence of SCH in normal population is estimated at 4-8.5%, but it was determined that in patients with infertility and in advanced age the incidence increases. 33 According to the current literature treatment of SCH is not established yet. In a prospective randomized study 64 SCH patients with infertility was delivered 50 mcg levothyroxine (LT4) in the first day of controlled ovarian stimulation (COH) and it was shown that having grade 1 and embryo, implantation and live birth rates were higher in the treatment group; but, no difference was found between groups regarding pregnancy rate per cycle.…”

Section: Subclinical Hypothyroidismmentioning

confidence: 99%

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Thyroid disorders and fertility

Karaca

Akpak

2015

Int J Res Med Sci

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Section: Autoimmune Thyroid Diseasesmentioning

confidence: 96%

Section: Subclinical Hypothyroidismmentioning

confidence: 99%

Thyroid disorders and fertility

Karaca

Akpak

2015

Int J Res Med Sci

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“…A high percentage of women with Chypo or SChypo become pregnant without being treated with T 4 (48). Abortion and stillbirth have been highly associated with TD, as well as endometriosis and ovarian failure, mostly in women with TAI (6).…”

Section: Obstetric Complications Associated With Td "mentioning

confidence: 99%

CONTROVERSIES IN ENDOCRINOLOGY: On the need for universal thyroid screening in pregnant women

Vila

Velasco

González

et al. 2014

European Journal of Endocrinology

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There is a well-known controversy among scientific societies regarding the recommendation to screen for thyroid dysfunction (TD) during pregnancy. Although several studies have shown an association between maternal subclinical hypothyroidism and/or hypothyroxinemia with obstetric problems and/or neurocognitive impairment in the offspring, there is only limited evidence on the possible positive effects of thyroxine (T 4 ) treatment in such cases. Despite the scarcity of this evidence, there is a widespread agreement among clinicians on the need for treatment of clinical hypothyroidism during pregnancy and the risks that could arise due to therapeutic abstention. As maternal TD is a quite prevalent condition, easily diagnosed and for which an effective and safe treatment is available, some scientific societies have proposed to assess thyroid function during the first trimester of pregnancy and ideally before week 10 of gestational age. Given the physiologic changes of thyroid function during pregnancy, hormone assessment should be performed using trimester-specific reference values ideally based on locally generated data as geographic variations have been detected. Screening of TD should be based on an initial determination of TSH performed early during the first trimester and only if abnormal should it be followed by either a free or total T 4 measurement. Furthermore, adequate iodine supplementation during pregnancy is critical and if feasible it should be initiated before the woman attempts to conceive.

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“…Effects of maternal hypothyroidism on offspring health are important in human [1] and veterinary medicine [2]. Previously, in the rat model, we have shown that maternal hypothyroidism during pregnancy and lactation leads to premature ovarian failure of pubertal and adult offspring [3].…”

Section: Introductionmentioning

confidence: 99%

Z-cells and oogonia/oocytes in the advanced process of autophagy are the dominant altered cells in the ovaries of hypothyroid newborn rats

et al. 2017

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Induced prenatal hypothyroidism in rat pups leads to accelerated primordial follicle assembly and premature follicular atresia with ovary failure. This work investigates the infl uence of maternal hypothyroidism induced with 6-n-propyl-2-thyouracil (PTU) on the number and morphology of oogonia/oocytes in newborn rat pups with light and transmission electron microscopy. Expression of apoptosis and autophagy markers in oogonia/oocytes were examined using immunohistochemistry. Hypothyroid newborn pups had a decreased number of mitotic and resting oogonia, while the number of altered oogonia/oocytes was increased. Ultrastructural observations revealed the increased presence of degenerated pachytene oocytes (Z-cells) and oogonia/oocytes undergoing autophagy, apoptosis and combined apoptosis and autophagy, in this group. The most abundant altered oogonia/oocytes in the hypothyroid group were those with morphological features of advanced autophagy and Z-cells. The percentage of TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) positive oogonia/ oocytes was signifi cantly lower in the hypothyroid group. No signifi cant difference was recorded in the expression of caspase-3, ATG7 and LC3 possibly refl ecting that these proteins were not involved in the oogonia/oocyte alteration process during prenatal rat hypothyroidism. The obtained results indicate that developmental hypothyroidism in the offspring enhances the number of Z-cells and oogonia/oocytes altered with the advanced process of autophagy.

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Subclinical hypothyroidism and thyroid autoimmunity in women with infertility

Abstract: We observed a higher prevalence of SH, but not of TAI, in patients with infertility. Our results support thyroid screening in women with reproductive failure.

Cited by 173 publications

References 37 publications

Thyroid disorders and fertility

Thyroid disorders and fertility

CONTROVERSIES IN ENDOCRINOLOGY: On the need for universal thyroid screening in pregnant women

Z-cells and oogonia/oocytes in the advanced process of autophagy are the dominant altered cells in the ovaries of hypothyroid newborn rats

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