Subclinical Hypothyroidism in a Biethnic, Urban Community

Lindeman, Robert D.; Schade, David S.; LaRue, Asenath; Romero, Linda J.; Liang, Hwa Chi; Baumgartner, Richard N.; Koehler, Kathleen M.; Garry, Philip J.

doi:10.1111/j.1532-5415.1999.tb01593.x

Cited by 118 publications

(58 citation statements)

References 33 publications

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“…Thus, TSH may be a less sensitive and more indirect measure of actual TH activity and CNS availability, thereby attenuating the relationship between TSH and cognitive performance in euthyroid individuals [19]. As in our study that showed no relationship between tT 3 and cognition, previous studies have also failed to identify a significant relationship between cognitive function and T 3 concentrations [20,21,28]. However, another study supported an association between the variability of T 3 levels within the normal range and cognitive dysfunctions [29,30].…”

Section: Discussioncontrasting

confidence: 53%

Thyroid Status and Cognitive Function in Euthyroid Patients with Early Parkinson's Disease

Choi

Kim²,

Choi³

et al. 2014

Dement Geriatr Cogn Disord

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Background: Alterations in thyroid hormone (TH) levels may be related to the pathogenesis of mild cognitive impairment (MCI) and dementia. Cognitive deficits are common in Parkinson's disease (PD) patients. The aim of this study was to investigate whether variations within the normal ranges of thyroid function are related to cognitive function in early PD without dementia. Methods: Eighty-four euthyroid patients with early PD underwent evaluation of their thyroid status, including measures of thyroid-stimulating hormone (TSH), total triiodothyronine (tT₃) and free thyroxine (fT₄), and comprehensive neuropsychological tests. Results: The 46 patients of the PD-MCI group did not differ in the serum levels of TH compared to the 38 patients of the PD-normal cognition group. fT₄ levels were inversely associated with the Mini-Mental State Examination (MMSE) score and neuropsychological tests of attention and visuospatial and executive function. TSH and tT₃ levels were not related to cognitive performances. After controlling for demographic and clinical variables, multiple regression analyses indicated statistically significant associations between fT₄ concentrations and MMSE score and neuropsychological tests of executive function. Conclusions: This study supports a relationship between the thyroid status and cognitive function in euthyroid early PD patients, with higher concentrations of fT₄ being associated with a poor performance of executive function.

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Section: Discussioncontrasting

confidence: 53%

Thyroid Status and Cognitive Function in Euthyroid Patients with Early Parkinson's Disease

Choi

Kim²,

Choi³

et al. 2014

Dement Geriatr Cogn Disord

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“…Additionally, the mere association between SHypo and psychiatric disorders should not lead to the conclusion that SHypo brings about these associated disorders. The four large epidemiological studies that examined cognitive and affective scores in SHypo subjects found few32 33 or no34 35 significant differences overall, and none in those with TSH between 5 mIU/l and 10 mIU/l.…”

Section: Subclinical Hypothyroidismmentioning

confidence: 99%

Subclinical thyroid disorders: significance and clinical impact

2010

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Subclinical thyroid diseases are defined by abnormal serum thyroid stimulating hormone (TSH) levels associated with normal thyroid hormone concentrations. The diagnosis of these conditions depends on defining the 'normal' euthyroid TSH range; in this review, arguments for and against lowering the upper limit of TSH are summarised. Although, subclinical hypothyroidism and subclinical hyperthyroidism are frequently encountered, their long-term consequences are debated due to conflicting results from many observational studies. The causes, effects and outcomes of treatment of both subclinical diseases are described, and the direction of future research in these conditions is outlined.

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“…Nevertheless, taken together, the results suggest that evaluation and treatment of subclinical hypothyroidism in the elderly may be beneficial in view of its prevalence and its potential clinical importance. Indeed, subclinical hypothyroidism is common with estimates ranging from 5% to 17% in the general population, with an age-related increase to as many as 20% of women and 9.5% of men over the age of 60 years [6, 22, 33, 36–39]. The prevalence of subclinical hypothyroidism in men over the age of 74 years was 16% which approaches the 21% prevalence seen in women of the same age [40].…”

Section: Cognitive Impairment In Subclinical Hypothyroidismmentioning

confidence: 99%

Thyroid Function and Cognition during Aging

Bégin

Langlois

Lorrain

et al. 2008

Current Gerontology and Geriatrics Research

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We summarize here the studies examining the association between thyroid function and cognitive performance from an aging perspective. The available data suggest that there may be a continuum in which cognitive dysfunction can result from increased or decreased concentrations of thyroid hormones. Clinical and subclinical hypothyroidism as well as hyperthyroidism in middle-aged and elderly adults are both associated with decreased cognitive functioning, especially memory, visuospatial organization, attention, and reaction time. Mild variations of thyroid function, even within normal limits, can have significant consequences for cognitive function in the elderly. Different cognitive deficits possibly related to thyroid failure do not necessarily follow a consistent pattern, and L-thyroxine treatment may not always completely restore normal functioning in patients with hypothyroidism. There is little or no consensus in the literature regarding how thyroid function is associated with cognitive performance in the elderly.

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Subclinical Hypothyroidism in a Biethnic, Urban Community

Cited by 118 publications

References 33 publications

Thyroid Status and Cognitive Function in Euthyroid Patients with Early Parkinson's Disease

Thyroid Status and Cognitive Function in Euthyroid Patients with Early Parkinson's Disease

Subclinical thyroid disorders: significance and clinical impact

Thyroid Function and Cognition during Aging

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