Subclinical Neuropathy at “Safe” Levels of Lead Exposure

Seppäläinen, Anna Maria; Tola, S; Hernberg, Sven; Kock, B

doi:10.1080/00039896.1975.10666672

Cited by 157 publications

(57 citation statements)

References 4 publications

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“…There are several reports of marked delay of CV in lead-handling workers, although no abnormalities of the nerves have been noted (14)(15)(16). However, in our patients, no decreases in CV were noted.…”

Section: Systems It Is Appropriate To Discuss the Form Of Lead Involcontrasting

confidence: 49%

Two cases of acute lead poisoning due to occupational exposure to lead

Ogawa

Nakajima

Kubota

et al. 2008

Clinical Toxicology

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Case Reports. We experienced two cases of acute lead poisoning due to occupational exposure to lead. The patients were engaged in stripping off antirust compounds including Pb from a bridge and re-painting it at the same work place. Both patients exhibited colic, arthralgia, and anemia. Blood lead levels were 73.1 μg/dl and 96.3 μg/dl. Intravenous CaEDTA chelation therapy was therefore performed. After chelation, blood lead levels decreased and symptoms gradually disappeared. Discussion. Although the patients were working with protective equipment, the workplace was in the mountains and there was no water for washing. The patients were thus unable to washing their hands and faces. We assume that they swallowed lead dust left on their hands and faces when they removed their clothing, and believe that this poisoning occurred due to lack of knowledge sufficient for protection.

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Section: Systems It Is Appropriate To Discuss the Form Of Lead Involcontrasting

confidence: 49%

Two cases of acute lead poisoning due to occupational exposure to lead

Ogawa

Nakajima

Kubota

et al. 2008

Clinical Toxicology

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“…In the first of these studies, Seppalainen et al found evidence for asymptomatic slowing of motor nerve conduction velocity in workers whose blood lead levels had never exceeded 70 jLg/dL (28). Araki et al found similar, asymptomatic dose-related slowing of motor nerve conduction (29).…”

Section: Neurologic ¶Bxicitymentioning

confidence: 62%

Current issues in the epidemiology and toxicology of occupational exposure to lead.

Landrigan

1990

Environ Health Perspect

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Occupational exposure to lead is widespread in the United States. Clinically evident lead poisoning as well as subclinical toxicity occur in populations with occupational lead exposure. The focus of current research on lead toxicity in industrial populations is in the definition of dose-response relationships, particularly at low levels of exposure. Major interest surrounds the development of biochemical and physiologic markers of subclinical toxicity. Need exists to better delineate the toxicity of lead on the peripheral and central nervous system, the kidneys, the cardiovascular system, and the reproductive organs using newly developed markers 'lb obtain more accurate information on cumulative individual exposure to lead, future research on lead toxicity will increasingly use X-ray fluorescence analysis for determination of the lead content in bone.

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“…Esse resultado é consonante com vários trabalhos internacionais, que evidenciaram retardo da velocidade de condução do impulso nervoso -não apenas do nervo radial, mas também dos nervos mediano, ulnar, tibial posterior, sural -em trabalhadores com indicadores biológicos de exposição ao chumbo semelhantes ou menores que os LTB brasileiros 1,7,12,20,21,29,30,32,41 . Para melhor comparação dos resultados com a literatura internacional especializada, veja-se Cordeiro e Lima Filho 14 (1995).…”

Section: Discussionunclassified

Distúrbios neurológicos em trabalhadores com baixos níveis de chumbo no sangue. I: Neuropatia periférica

Cordeiro¹,

Filho

Salgado

1996

Rev. Saúde Pública

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.S.)Resumo Trata-se de estudo observacional, transversal, em população aleatorizada, cujo objetivo foi contribuir para a avaliação da validade dos limites de tolerância biológica (LTB) estabelecidos no Brasil para a plumbemia (Pb-S) e a concentração urinária do ácido δ-aminolevulínico (ALA-U). Para tanto, um grupo de trabalhadores expostos ao chumbo, cujos valores de Pb-S e ALA-U encontravam-se no momento do estudo -bem como nos 2 anos precedentesabaixo dos LTB brasileiros, foi submetido a exame eletroneurográfico dos nervos mediano direito, ciático-popliteo externo direito, radial direito, radial esquerdo e sural direito. Os resultados foram comparados com os obtidos por intermédio da aplicação do mesmo conjunto de exames em um grupo-controle não exposto ao chumbo. No grupo exposto foram encontrados sinais de comprometimento dos nervos radiais -que diferiam significativamente dos resultados obtidos no grupo-controle (p = 0,0067). Os resultados apontam contra a validação dos LTB estabelecidos no Brasil para a Pb-S e a ALA-U.

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Subclinical Neuropathy at “Safe” Levels of Lead Exposure

Cited by 157 publications

References 4 publications

Two cases of acute lead poisoning due to occupational exposure to lead

Two cases of acute lead poisoning due to occupational exposure to lead

Current issues in the epidemiology and toxicology of occupational exposure to lead.

Distúrbios neurológicos em trabalhadores com baixos níveis de chumbo no sangue. I: Neuropatia periférica

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